【摘要】 目的 探討燈盞花素注射液聯(lián)合血管緊張素轉(zhuǎn)換酶抑制劑（ACEI）依那普利治療糖尿病早期腎病的臨床效果?！》椒ā?006年10月-2009年12月，將59例臨床確診2型糖尿病早期腎病的患者隨機(jī)分為治療組（n=30）與對(duì)照組（n=29）。對(duì)照組在基本治療的基礎(chǔ)上應(yīng)用依那普利，治療組在基本治療的基礎(chǔ)上聯(lián)合應(yīng)用依那普利和燈盞花素注射液，療程均為3周。觀察治療前后兩組患者24 h尿微量白蛋白排泄率（UAER）、全血黏度、血漿黏度、甘油三酯（TG）、尿素氮（BUN）、血肌酐（SCr）的變化?！〗Y(jié)果 兩組患者治療前后自身對(duì)比，24 h UAER均有明顯下降（Plt;0.05）；治療組UAER下降較對(duì)照組更為明顯（Plt;0.05）?！〗Y(jié)論 ACEI聯(lián)合燈盞花素，其降低24 h UAER療效優(yōu)于單純ACEI療效，還可有效降低全血黏度和血漿黏度，降低纖維蛋白原含量，改善患者血液流變性?！続bstract】 Objective To investigate the therapeutic effects of breviscapine combined with angiotensin converting enzyme inhibitor (enalapril) on early diabetic nephropathy. Methods A total of 59 patients with early diabetic nephropathy diagnosed between October 2006 and December 2009 were randomly divided into treatment group (n=30) and control group (n=29). The patients in treatment group were treated by breviscapine combined with enalapril, while the patients were treated with only enalapril in the control group. All of the patients were treated for three weeks. Urinaryalbuminexcretion (UAE), whole blood viscosity, plasma viscosity, triglycercide, blood urea nitrogen and serum creatinine in the two groups were detected before and after the treatment. Results After the threatment, UAE decreased in both of the two groups compared with the value before the treatment (Plt;0.05); the decrease in treatment groups was more obvious than that in the control group (Plt;0.05). Conclusion The combination of breviscapine and enalapril is effective on early diabetic nephropathy.
目的 探討血尿酸與胰島素分泌和敏感性的關(guān)系。 方法 對(duì)成都市龍泉驛區(qū)2007年6月－7月間20～75歲常住自然人群565人進(jìn)行人口學(xué)、腰圍、臀圍、血壓、75 g葡萄糖耐量及胰島素測(cè)定（0、30、120 min），血脂、血肌酐及血尿酸檢測(cè)。以早期胰島素分泌功能指數(shù)（△I30/△G30）和葡萄糖處置指數(shù)（DIo）代表胰島素分泌功能，以Matsuda 指數(shù)代表胰島素敏感性，分別與血尿酸進(jìn)行相關(guān)性研究。 結(jié)果 男性的血尿酸與年齡呈負(fù)相關(guān)，與舒張壓、葡萄糖負(fù)荷后120 min胰島素和甘油三酯呈正相關(guān)。女性的血尿酸與甘油三酯、低密度脂蛋白、血肌酐呈正相關(guān)，與高密度脂蛋白、Matsuda指數(shù)呈負(fù)相關(guān)。無(wú)論男性和女性，均未發(fā)現(xiàn)血尿酸與△I30/△G30、DIo相關(guān)。 結(jié)論 女性的胰島素敏感性下降與血尿酸升高有關(guān)。未發(fā)現(xiàn)血尿酸與胰島素分泌有相關(guān)關(guān)系。