【摘要】 目的 探討燈盞花素注射液聯(lián)合血管緊張素轉(zhuǎn)換酶抑制劑（ACEI）依那普利治療糖尿病早期腎病的臨床效果。 方法 2006年10月-2009年12月，將59例臨床確診2型糖尿病早期腎病的患者隨機(jī)分為治療組（n=30）與對(duì)照組（n=29）。對(duì)照組在基本治療的基礎(chǔ)上應(yīng)用依那普利，治療組在基本治療的基礎(chǔ)上聯(lián)合應(yīng)用依那普利和燈盞花素注射液，療程均為3周。觀察治療前后兩組患者24 h尿微量白蛋白排泄率（UAER）、全血黏度、血漿黏度、甘油三酯（TG）、尿素氮（BUN）、血肌酐（SCr）的變化。 結(jié)果 兩組患者治療前后自身對(duì)比，24 h UAER均有明顯下降（P lt;0.05）；治療組UAER下降較對(duì)照組更為明顯（P lt;0.05）。 結(jié)論 ACEI聯(lián)合燈盞花素，其降低24 h UAER療效優(yōu)于單純ACEI療效，還可有效降低全血黏度和血漿黏度，降低纖維蛋白原含量，改善患者血液流變性。
【Abstract】 Objective To investigate the therapeutic effects of breviscapine combined with angiotensin converting enzyme inhibitor (enalapril) on early diabetic nephropathy. Methods A total of 59 patients with early diabetic nephropathy diagnosed between October 2006 and December 2009 were randomly divided into treatment group (n=30) and control group (n=29). The patients in treatment group were treated by breviscapine combined with enalapril, while the patients were treated with only enalapril in the control group. All of the patients were treated for three weeks. Urinaryalbuminexcretion (UAE), whole blood viscosity, plasma viscosity, triglycercide, blood urea nitrogen and serum creatinine in the two groups were detected before and after the treatment. Results After the threatment, UAE decreased in both of the two groups compared with the value before the treatment (P lt;0.05); the decrease in treatment groups was more obvious than that in the control group (P lt;0.05). Conclusion The combination of breviscapine and enalapril is effective on early diabetic nephropathy.
引用本文： 鐘莉,黎珂. 燈盞花素注射液結(jié)合依那普利治療早期糖尿病腎病臨床療效評(píng)價(jià). 華西醫(yī)學(xué), 2011, 26(4): 493-495. doi: 復(fù)制
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- 1. 張惠芬, 遲家敏, 王瑞萍, 等. 糖尿病腎病[M]. 2版. 北京: 人民衛(wèi)生出版社, 2004: 247.
- 2. Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease podocyte injury comes of age in diabetic nephropathy[J]. Diabetes, 2005, 54(6): 1626-1634.
- 3. 占永力, 岳玉和, 周靜媛, 等. 中藥三七注射液對(duì)顯性糖尿病腎病并高凝狀態(tài)的影響[J]. 中國中西醫(yī)結(jié)合腎病雜志, 2002, 3(1): 23-25.
- 4. 李春保, 王林輝, 梅小斌. 糖尿病性腎病[M]. 上海: 第二軍醫(yī)大學(xué)出版社, 2005: 24-25.
- 5. 郭永兵. 燈盞細(xì)辛、 黃芪注射液聯(lián)合苯那普利治療IgA腎病伴慢性腎功能不全[J]. 中原醫(yī)刊, 2006, 33(15): 9-11.
- 6. 杜飛, 高原, 姚君, 等. 燈盞花素對(duì)高糖環(huán)境近端小管上皮細(xì)胞鈉鉀ATP酶活性的影響[J]. 第三軍醫(yī)大學(xué)學(xué)報(bào), 2008, 30(23): 2242-2243.
- 7. Scherzer P, Popovtzer MM. Segmental localization of mRNAs encoding Na+-K+-ATPase α1 and β1-subunits in diabetic rat kidneys using RT-PCR[J]. Am J Physiol Renal Physiol, 2002, 282(3): 492-500.
- 8. 沈東波, 高原, 杜飛. 燈盞花素在大鼠糖尿病早期對(duì)近球小管鈉鉀ATP酶活性的影響[J]. 中國藥理學(xué)通報(bào), 2007, 23(7): 917-920.
- 9. 肖華, 楊秋萍. 燈盞花素對(duì)糖尿病大鼠腎組織NF-κB和腎功能影響的實(shí)驗(yàn)研究[J]. 陜西中醫(yī), 2008, 29(5): 624-626.