【摘要】 目的 探討膿毒性休克早期液體復(fù)蘇的臨床反應(yīng)性。 方法 對2008年2月—2010年2月38例采用早期目標(biāo)定向治療方案治療的膿毒性休克患者按是否存活進行分組，就中心靜脈壓、心率、平均動脈壓、輸液量、尿量、血乳酸等指標(biāo)進行評價。 結(jié)果 38例采用早期目標(biāo)定向治療方案治療6 h均達標(biāo)，存活21例（55.26%），死亡17例（44.74%），兩組患者輸液總量及輸液種類差異無統(tǒng)計學(xué)意義（Pgt;0.05），存活組6、24 h尿量及血乳酸清除率明顯優(yōu)于死亡組（Plt;0.05）。 結(jié)論 血乳酸清除率及尿量可作為膿毒性休克液體復(fù)蘇有效的臨床監(jiān)測指標(biāo)?！続bstract】 Objective To study the clinical response to early fluid resuscitation therapy in septic shock patients. Methods Thirty-eight septic shock patients received early goal-directed therapy (EGDT) in the ICU of our hospital from February 2008 to February 2010. The patients were divided into survival group (n=21) and dead group (n=17). Indexes like central venous pressure (CVP), heart rate (HR), mean arterial pressure (MAP), fluid input, urine output, and blood lactate were evaluated. Results Six hours after the EGDT, the results for the patients were all up to standard. There were 21 cases of survival (55.26%) and 17 cases of death (44.74%). The total fluid input and liquid types were similar in the two groups (Pgt;0.05). The urine output and lactate clearance at hour 6 and 24 for the survival group were better than that for the dead group (Plt;0.05). Conclusion The lactate clearance and urine output can be regarded as an surveillance indicator of fluid resuscitation for patients with septic shock.