• 山東醫(yī)科大學(xué)附屬醫(yī)院普外科(濟(jì)南250012);

目的  探討p16蛋白與雌激素受體在甲狀腺乳頭狀癌發(fā)生發(fā)展中的作用及其相關(guān)性。
方法  應(yīng)用免疫組化法對50例甲狀腺乳頭狀癌標(biāo)本進(jìn)行p16蛋白及雌激素受體檢測。
結(jié)果  p16蛋白表達(dá)及雌激素受體與甲狀腺乳頭狀癌的組織分化、淋巴結(jié)轉(zhuǎn)移及預(yù)后有關(guān)。
結(jié)論  p16蛋白表達(dá)與雌激素受體水平有助于甲狀腺癌的分化及預(yù)后的判斷。

引用本文: 劉軍,王占民,王磊. 甲狀腺乳頭狀癌的p16蛋白與雌激素受體表達(dá)及其相關(guān)性研究. 中國普外基礎(chǔ)與臨床雜志, 2000, 7(5): 295-296. doi: 復(fù)制

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2. Miki H, Oshimo K, Inoue H, et al. Sex hormone receptor in human thyroid tissues 〔J〕. Cancer, 1990; 66(8)∶1759.
3. 劉軍, 王占民, 張?zhí)? 甲狀腺乳頭狀癌性激素受體的檢測 〔J〕. 山東醫(yī)科大學(xué)學(xué)報(bào), 1999; 37(4)∶331.
4. Yane K, Konishi N, Kitahori Y, et al. Lack of p16/CDKN2 alterations in thyroid carcinomas 〔J〕. Cancer Lett, 1996; 101(1)∶85.
5. Reed JA, Loganzo FJr, Shea CR, et al. Loss expression of the p16/cyclindependent kinase inhibitor 2 tumor suppressor gene inmelanocytic lesions correlates with invasive stage of tumor progression 〔J〕. Cancer Res, 1995; 55(10)∶2713.
6. 郭山春, 廖松林, 丁華野等. 乳腺癌p16基因表達(dá)與增殖細(xì)胞核抗原指數(shù)的相關(guān)性 〔J〕. 中華醫(yī)學(xué)雜志, 1997; 77(7)∶529.
7. Wadih A, Ryo N, Frank B, et al. Replacement of the p16/CDKN2 gene suppresses human gliioma cell growth 〔J〕. Cancer Res, 1995; 55(3)∶1351.
8. VanHoeven, MenendezBotet, Elliot W, et al. Estrogen and progesterone receptor content in human thyroid diseases 〔J〕. Am J Clin Pathol, 1993; 99(2)∶175.
  1. 1. Paloyan E, Hofmann C, Richard A, et al. Gastriation induces a marked reduction in the incidence of thyroid cancers 〔J〕. Surgery, 1982; 92(5)∶839.
  2. 2. Miki H, Oshimo K, Inoue H, et al. Sex hormone receptor in human thyroid tissues 〔J〕. Cancer, 1990; 66(8)∶1759.
  3. 3. 劉軍, 王占民, 張?zhí)? 甲狀腺乳頭狀癌性激素受體的檢測 〔J〕. 山東醫(yī)科大學(xué)學(xué)報(bào), 1999; 37(4)∶331.
  4. 4. Yane K, Konishi N, Kitahori Y, et al. Lack of p16/CDKN2 alterations in thyroid carcinomas 〔J〕. Cancer Lett, 1996; 101(1)∶85.
  5. 5. Reed JA, Loganzo FJr, Shea CR, et al. Loss expression of the p16/cyclindependent kinase inhibitor 2 tumor suppressor gene inmelanocytic lesions correlates with invasive stage of tumor progression 〔J〕. Cancer Res, 1995; 55(10)∶2713.
  6. 6. 郭山春, 廖松林, 丁華野等. 乳腺癌p16基因表達(dá)與增殖細(xì)胞核抗原指數(shù)的相關(guān)性 〔J〕. 中華醫(yī)學(xué)雜志, 1997; 77(7)∶529.
  7. 7. Wadih A, Ryo N, Frank B, et al. Replacement of the p16/CDKN2 gene suppresses human gliioma cell growth 〔J〕. Cancer Res, 1995; 55(3)∶1351.
  8. 8. VanHoeven, MenendezBotet, Elliot W, et al. Estrogen and progesterone receptor content in human thyroid diseases 〔J〕. Am J Clin Pathol, 1993; 99(2)∶175.