• 1新疆醫(yī)科大學,新疆烏魯木齊 830001; 2新疆維吾爾自治區(qū)人民醫(yī)院,新疆烏魯木齊 830002;

目的:觀察七氟醚靶控用于低流量吸入麻醉維持的臨床規(guī)律及血流動力學變化,尋求靶控下的藥物量化指標。方法:選擇60例20～60歲手術患者,隨機分2組每組30例:P組(丙泊酚)常規(guī)實施全憑靜脈TCI靶控麻醉;S組(七氟醚),實施低流量七氟醚靶控吸入麻醉(BIS值40)。分別記錄誘導前(T1),插管后5(T2)、15(T3)、30(T4)45(T5)、60(T6)、90(T7)、120(T8)min時的、MBP、HR、;Sev組患者加記各個時點的七氟醚IT、ET的MAC值。結果:T2點兩組均比T1 降低(P lt;0.05),S 組高于P組(P lt;0.05),兩組比較T3至T7無顯著性差異(P gt;0.05);S 組T3 至T7 各點ET值無統(tǒng)計學差異,ET%:2.46,約1.4 MAC。結論:(1)七氟醚誘導較靜脈麻醉誘導患者血流動力學穩(wěn)定,(2)低流量七氟醚靶控吸入麻醉維持平穩(wěn),調控簡便,效果良好。

引用本文： 蘇濤,王在義,伍湘伊,徐桂萍. 低流量七氟醚靶控吸入與丙泊酚TCI的臨床對比研究. 華西醫(yī)學, 2009, 24(7): 1695-1698. doi: 復制

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  3. 3. MALAN TPJ, DINARDO J A, ISNER R J, et al. Cardiovascular effects of servo fluraneeom Pared with those of isofiurane in volunteers[J]. Anesthesiology,1995,83:918-28.
  4. 4. MAPLESON W W. Effec to fageon MAC analysis[J].Br J Anaesth,1996,76:179-85.
  5. 5. EGER EL ZND, SAIDNLAN L J, BRANDSTATER B. Minimum alveolar anesthetic concentration:a standard of anesthetic potency[J].Anesthesiology,1965,26:756-63.
  6. 6. KEIJZER C, PEREZ R S, DE LANGE J J. Compound A and carbon monoxide production from sevoflurane and seven different types of carbon dioxide absorbent in a patient model[J]. Acta Anaesthesiol Scand, 2007, 51:31-37.