目的:研究心肌灌注顯像(MPI)經(jīng)CT衰減校正(CTAC)后偽影的產(chǎn)生及其對(duì)臨床診斷的影響。方法:回顧性分析按Bayesian理論,冠心病患病率<5%的48例受檢者所行的72例次MPI(負(fù)荷41例次,靜息31例次),圖像在未行CTAC時(shí)顯示正常者進(jìn)行研究。將左心室心肌劃分為20個(gè)節(jié)段,半定量分析(0分=放射性分布正常;1分=放射性分布輕度減低;2分=放射性分布中度降低;3分=放射性分布重度減低;4分=放射性分布缺損)各心肌節(jié)段在CTAC后放射性分布變化情況。結(jié)果:72例次MPI中,16例次(22.2%)的75個(gè)心肌節(jié)段(均在左心室心尖、前壁、前間壁區(qū)域)在CTAC后出現(xiàn)了放射性分布不同程度的減低。75個(gè)受累節(jié)段中分別有51、21和3個(gè)節(jié)段評(píng)分增加了1、2和3分,平均每個(gè)心肌節(jié)段評(píng)分增加了1.3分。41例次負(fù)荷MPI和31例次靜息MPI中,分別有9例次(21.9%)的39個(gè)心肌節(jié)段、7例次(22.6%)的36個(gè)心肌節(jié)段在CTAC后出現(xiàn)了放射性分布減低,負(fù)荷與靜息MPI相比,CTAC后發(fā)生心肌節(jié)段放射性分布減低的概率(χ2=2.84,P>0.05)與程度(u=0.54,P>0.05)均無(wú)顯著統(tǒng)計(jì)學(xué)差異。10例負(fù)荷/靜息MPI都滿足納入標(biāo)準(zhǔn)而納入研究者中,4例的負(fù)荷/靜息MPI在CTAC后,出現(xiàn)了相同部位(尖前壁、尖下壁)、相同程度(評(píng)分均增加了2分)的灌注降低;3例出現(xiàn)了同一部位,但不同程度的灌注減低;另有3例出現(xiàn)了不同部位心肌節(jié)段的灌注減低。CTAC后出現(xiàn)心肌節(jié)段灌注減低者與未出現(xiàn)者相比年齡、性別構(gòu)成無(wú)統(tǒng)計(jì)學(xué)差異。結(jié)論:分析SPECT/CT心肌灌注圖像時(shí),應(yīng)同時(shí)分析CTAC前后的灌注圖像。對(duì)于只在CTAC后出現(xiàn)的灌注缺損,需要考慮可能存在CT與SPECT圖像配位不準(zhǔn)。
引用本文: 四川大學(xué)華西醫(yī)院核醫(yī)學(xué)科,四川成都. 心肌灌注顯像CT衰減校正偽影產(chǎn)生的初步研究. 華西醫(yī)學(xué), 2009, 24(2): 388-391. doi: 復(fù)制
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- 2. Germano G,Slomka PJ,Berman DS.Attenuation correction in cardiac SPECT:the boy who cried wolf?[J]J Nucl Cardiol,2007,14:25-35..
- 3. Diamond GA,F(xiàn)orester JS.Analysis of probability as an aid in the clinical diagnosis of coronary artery disease[J].N Engl J Med,1979,300:1350-1358..
- 4. Port SC.Imaging guidelines for nuclear cardiology procedures[J].J Nucl Cardiol,1999,6:G67-G77..
- 5. Klocke FJ,Baird MG,Lorell BH,et al.ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging[J].Circulation,2003,108:1404-1418..
- 6. Gaemperli O,Schepis T,Valenta I,et al.Cardiac image fusion from standalone SPECT and CT:clinical experience[J].J Nucl Med,2007,48:696-703..
- 7. Goetze S,Wahl R.Prevalence of misregistration between SPECT and CT for attenuationcorrected myocardial perfusion SPECT[J].J Nucl Car diol,2007,14:200-206.
- 8. Fricke H,F(xiàn)ricke E,Weise R,et al.A method to remove artifacts in attenuation corrected myocardial perfusion SPECT introduced by misalignment between emission scan and CTderived attenuation maps[J].J Nucl Med,2004,45:1619-1625..
- 9. Goetze S,Brown T,Lavely WC,et al.Attenuation corrected in myocardial perfusion SPECT/CT:effects of misregistration and value of reregistration[J].J Nucl Med,2007,48:10901095.
- 10. Links Jm,Becker LC,Anstett F.Clinical significance of apical thinning after attenuation correction[J].J Nucl Cardiol,2004,11:26-31..
- 11. Chen J,CaputluWilson SF,Shi HC,et al.Automated quality control of emissiontransmission misaligment for attenuation correction in myocardial perfusion imaging with SPECTCT systems[J].J Nucl Cardiol,2006,13:43-49..
- 12. Heller GV,Links J,Bateman TM,et al.American Society of Nuclear Cardiology and Society of Nuclear Medicine Joint Statement:attenuation correction of myocardial perfusion SPECT scientigraphy[J].J Nucl Med,2004,45:229-230..