【摘要】 目的 總結(jié)曲美他嗪在缺血性擴(kuò)張型心肌病患者心功能改善方面的作用。 方法 2007年1月-2009年12月隨機(jī)將61例患者分為二組，觀察組給予常規(guī)藥物治療加用曲美他嗪，對(duì)照組給予常規(guī)治療，通過心功能及左心室射血分?jǐn)?shù)兩個(gè)方面來評(píng)估治療效果。 結(jié)果 觀察組較對(duì)照組顯著增加左室射血分?jǐn)?shù)，并能改善患者心功能分級(jí)。 結(jié)論 缺血性擴(kuò)張型心肌病患者可以很好地耐受較長(zhǎng)期的曲美他嗪治療，同時(shí)心功能也得到改善。
引用本文： 任靜,馮勝紅. 曲美他嗪治療缺血性擴(kuò)張型心肌病療效觀察. 華西醫(yī)學(xué), 2010, 25(11): 2060-2061. doi: 復(fù)制
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- 1. Di Napoli P, Taccardi AA, Bardotti A. Long term cardio-protective action of trimetazidine and potential effect on the inflammatory process in patients with ischemic dilated cardiomyopathy[J]. Heart, 2005, 92(2): 161-165.
- 2. 賈三慶, 董曉冬, 胡大一, 等. 曲美他嗪心肌細(xì)胞保護(hù)作用的臨床研究[J]. 中華心血管病雜志, 2003, 31(增刊): 201-208.
- 3. Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischmic cardiomyopathy[J]. Eur Heart J, 2001, 22(23): 2164-2170.
- 4. 謝瑞芹, 都軍, 郝玉明, 等. 曲美他嗪治療冠心病心力衰竭療效觀察[J]. 中華心血管病雜志, 2004, 32(1): 77.
- 5. 胡大一, 趙秀麗. 曲美他嗪對(duì)穩(wěn)定性勞力型心絞痛的療效觀察[J]. 中華心血管病雜志, 2000, 29(15): 18-20.
- 6. Guarnieri C, Muscari C. Effict of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischmic hypertrophied myocardium[J]. Pharmacology, 1993, 46: 324-331.
- 7. Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischmic cardiomyopathy[J]. Eur Heart J, 2001, 22: 2164-2170.
- 8. Lu C, Dabrowski P, Fracasso G, et al. Effects of trimetazidine on ischmic left ventricular dysfunction in patients with coronary disease: a doubleblind. Placebo-controlled, crossover study[J]. Am J Cardiol, 1998, 82: 898-901.