目的 比較尿毒癥患者使用國(guó)產(chǎn)高通量聚醚砜透析器和進(jìn)口聚砜膜血液透析器在血液透析中的有效性和安全性。
方法 選擇符合標(biāo)準(zhǔn)的血液透析患者40例，采用隨機(jī)數(shù)字表法生成隨機(jī)順序，將患者隨機(jī)分為聚醚砜組和聚砜組各20例，分別使用國(guó)產(chǎn)高通量聚醚砜血液透析器和進(jìn)口聚砜膜血液透析器進(jìn)行高通量透析4 h。以肌酐、尿素氮和血β2微球蛋白下降和透析前后外周血Hb、Alb等指標(biāo)的變化進(jìn)行療效和安全性評(píng)估。
結(jié)果 本研究納入的40例全部完成試驗(yàn)，無一例失訪。結(jié)果顯示，兩組受試者在使用兩種透析器透析后均可使血肌酐、尿素氮和血β2微球蛋白下降,且兩組的下降幅度相當(dāng)（P均 gt;0.05）。反應(yīng)透析充分性的指標(biāo)KT/V值的變化也顯示兩組透析的充分程度相當(dāng)（P gt;0.05）；而透析安全性的指標(biāo)如血Hb、Alb和血壓，在兩組透析前后差異無統(tǒng)計(jì)學(xué)意義。
結(jié)論 高通量聚醚砜透析器對(duì)尿毒癥患者進(jìn)行高通量透析，其療效和安全性與高通量聚砜透析器相當(dāng)。
引用本文： 蘇白海,李 孜,陶 冶,沙朝暉,付 平,趙長(zhǎng)生. 國(guó)產(chǎn)高通量聚醚砜血液透析器對(duì)尿毒癥患者進(jìn)行血液透析的隨機(jī)雙盲對(duì)照試驗(yàn). 中國(guó)循證醫(yī)學(xué)雜志, 2006, 06(7): 474-478. doi: 復(fù)制
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