• 南昌大學第二附屬醫(yī)院骨一科（南昌，330006）;

目的綜述阿侖膦酸鈉（alendronate，ALN）對骨關節(jié)炎（osteoarthritis，OA）關節(jié)軟骨保護作用的研究進展。 方法廣泛查閱近年國內(nèi)外相關文獻，并進行綜合分析。 結果ALN能改善OA關節(jié)軟骨代謝微環(huán)境，抑制軟骨下骨骨重塑，對關節(jié)軟骨有潛在保護作用。 結論ALN有望成為一種OA疾病改善藥物，但OA治療尚缺乏統(tǒng)一的基礎與臨床評價標準，制定統(tǒng)一標準并獲取臨床數(shù)據(jù)對ALN的開發(fā)和應用有指導性意義。

引用本文： 何丁文,殷明,羅元一,魏強強. 阿侖膦酸鈉對骨關節(jié)炎關節(jié)軟骨保護作用的研究進展. 中國修復重建外科雜志, 2012, 26(10): 1187-1190. doi: 復制

版權信息： ?四川大學華西醫(yī)院華西期刊社《中國修復重建外科雜志》版權所有，未經(jīng)授權不得轉(zhuǎn)載、改編

1. Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three issues. Bull NYU Hosp Jt Dis, 2008, 66(3): 244-250.
2. 王哲彥, 王文雅, 張柳. 骨性關節(jié)炎的發(fā)病機制及其與Wnt/β-catenin信號通路的關系. 中國矯形外科雜志, 2009, 17(23): 1800-1803.
3. Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone, 2006, 38(2): 234-243.
4. Qvist P, Bay-Jensen AC, Christiansen C, et al. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon. Pharmacol Res, 2008, 58(1): 1-7.
5. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.
6. Konttinen YT, Salo T, Hanemaaijer R, et al. Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol, 1999, 18(4): 401-412.
7. Heikkilä P, Teronen O, Moilanen M, et al. Bisphosphonates inhibit stromelysin-1(MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines. Anticancer Drugs, 2002, 13(3): 245-254.
8. 胡宏宇, 張柳, 李彬, 等. 阿侖膦酸鈉體外對軟骨細胞的影響及對兔前交叉韌帶切斷后關節(jié)軟骨和軟骨下骨的作用. 中國修復重建外科雜志, 2009, 23(12): 1474-1481.
9. 王哲彥, 王文雅, 張柳, 等. 阿侖膦酸鈉對IL-1β體外誘導培養(yǎng)的大鼠膝關節(jié)軟骨細胞影響的實驗研究. 中國修復重建外科雜志, 2011, 25(1): 50-55.
10. Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum, 2004, 50(4): 1193-1206.
11. 谷銳, 陳廖斌, 汪暉, 等. 阿侖膦酸鈉對大鼠骨關節(jié)炎影響的實驗研究. 武漢大學學報: 醫(yī)學版, 2009, 30(1): 66-69.
12. 婁方勇, 衛(wèi)小春. 阿侖膦酸鈉對骨質(zhì)疏松大鼠關節(jié)軟骨的影響. 中國藥物與臨床, 2009, 9(4): 261-264.
13. 梁祖建, 李釗, 張還添, 等. 福善美調(diào)控軟骨下骨骨重塑保護關節(jié)軟骨的機制研究. 中國骨質(zhì)疏松雜志, 2009, 15(3): 206-210.
14. 李強, 張柳, 李震, 等. 阿侖膦酸鈉對前交叉韌帶切斷大鼠關節(jié)軟骨退變的影響. 中國矯形外科雜志, 2010, 18(14): 1200-1204.
15. 程潭, 張柳, 李震, 等. 阿侖膦酸鈉對兔膝骨關節(jié)炎關節(jié)軟骨及軟骨下骨保護的作用. 中國老年學雜志, 2010, 30(24): 3695-3698.
16. Shirai T, Kobayashi M, Nishitani K, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res, 2011, 29(10): 1572-1577.
17. Zhang L, Hu H, Tian F, et al. Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental. Clin Exp Med, 2011, 11(4): 235-243.
18. Hayami T, Zhuo Y, Wesolowski GA, et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone, 2012, 50(6): 1250-1256.
19. Panahifar A, Maksymowych WP, Doschak MR. Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis Cartilage, 2012, 20(7): 694-702.
20. 柯賢柱, 石芳, 李飛. 阿侖膦酸鈉聯(lián)合骨肽注射液治療膝骨性關節(jié)炎療效分析. 中國誤診學雜志, 2011, 11(31): 7646-7647.
21. 李亞芹. 針刀松解術聯(lián)合阿侖膦酸鈉治療膝關節(jié)退行性骨病. 臨床和實驗醫(yī)學雜志, 2011, 10(11): 853, 856.
22. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.
  1. 1. Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three issues. Bull NYU Hosp Jt Dis, 2008, 66(3): 244-250.
  2. 2. 王哲彥, 王文雅, 張柳. 骨性關節(jié)炎的發(fā)病機制及其與Wnt/β-catenin信號通路的關系. 中國矯形外科雜志, 2009, 17(23): 1800-1803.
  3. 3. Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone, 2006, 38(2): 234-243.
  4. 4. Qvist P, Bay-Jensen AC, Christiansen C, et al. The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon. Pharmacol Res, 2008, 58(1): 1-7.
  5. 5. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.
  6. 6. Konttinen YT, Salo T, Hanemaaijer R, et al. Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate. Matrix Biol, 1999, 18(4): 401-412.
  7. 7. Heikkilä P, Teronen O, Moilanen M, et al. Bisphosphonates inhibit stromelysin-1(MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines. Anticancer Drugs, 2002, 13(3): 245-254.
  8. 8. 胡宏宇, 張柳, 李彬, 等. 阿侖膦酸鈉體外對軟骨細胞的影響及對兔前交叉韌帶切斷后關節(jié)軟骨和軟骨下骨的作用. 中國修復重建外科雜志, 2009, 23(12): 1474-1481.
  9. 9. 王哲彥, 王文雅, 張柳, 等. 阿侖膦酸鈉對IL-1β體外誘導培養(yǎng)的大鼠膝關節(jié)軟骨細胞影響的實驗研究. 中國修復重建外科雜志, 2011, 25(1): 50-55.
  10. 10. Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum, 2004, 50(4): 1193-1206.
  11. 11. 谷銳, 陳廖斌, 汪暉, 等. 阿侖膦酸鈉對大鼠骨關節(jié)炎影響的實驗研究. 武漢大學學報: 醫(yī)學版, 2009, 30(1): 66-69.
  12. 12. 婁方勇, 衛(wèi)小春. 阿侖膦酸鈉對骨質(zhì)疏松大鼠關節(jié)軟骨的影響. 中國藥物與臨床, 2009, 9(4): 261-264.
  13. 13. 梁祖建, 李釗, 張還添, 等. 福善美調(diào)控軟骨下骨骨重塑保護關節(jié)軟骨的機制研究. 中國骨質(zhì)疏松雜志, 2009, 15(3): 206-210.
  14. 14. 李強, 張柳, 李震, 等. 阿侖膦酸鈉對前交叉韌帶切斷大鼠關節(jié)軟骨退變的影響. 中國矯形外科雜志, 2010, 18(14): 1200-1204.
  15. 15. 程潭, 張柳, 李震, 等. 阿侖膦酸鈉對兔膝骨關節(jié)炎關節(jié)軟骨及軟骨下骨保護的作用. 中國老年學雜志, 2010, 30(24): 3695-3698.
  16. 16. Shirai T, Kobayashi M, Nishitani K, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res, 2011, 29(10): 1572-1577.
  17. 17. Zhang L, Hu H, Tian F, et al. Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental. Clin Exp Med, 2011, 11(4): 235-243.
  18. 18. Hayami T, Zhuo Y, Wesolowski GA, et al. Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone, 2012, 50(6): 1250-1256.
  19. 19. Panahifar A, Maksymowych WP, Doschak MR. Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis Cartilage, 2012, 20(7): 694-702.
  20. 20. 柯賢柱, 石芳, 李飛. 阿侖膦酸鈉聯(lián)合骨肽注射液治療膝骨性關節(jié)炎療效分析. 中國誤診學雜志, 2011, 11(31): 7646-7647.
  21. 21. 李亞芹. 針刀松解術聯(lián)合阿侖膦酸鈉治療膝關節(jié)退行性骨病. 臨床和實驗醫(yī)學雜志, 2011, 10(11): 853, 856.
  22. 22. Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int, 2008, 82(1): 77-86.