• 中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院 國家心血管病中心 阜外心血管病醫(yī)院 心血管疾病國家重點(diǎn)實(shí)驗(yàn)室 體外循環(huán)科,北京 100037;

血管加壓素(arginine vasopressin,AVP)與多種心血管疾病和腎臟疾病的發(fā)生相關(guān),目前主要用于治療嚴(yán)重的外周血管擴(kuò)張性休克,對(duì)于常規(guī)兒茶酚胺治療效果不佳的患者尤為有效。心血管外科術(shù)后部分患者體內(nèi)存在血管加壓素相對(duì)不足,給予外源性血管加壓素能夠降低心率、減少兒茶酚胺類的使用量和使用時(shí)間。早期應(yīng)用小劑量的血管加壓素可能有助于患者術(shù)后血流動(dòng)力學(xué)的恢復(fù),而不會(huì)造成并發(fā)癥的發(fā)生。進(jìn)一步的隨機(jī)對(duì)照試驗(yàn),將為血管加壓素的合理使用和劑量、療程選擇提供依據(jù)。

引用本文: 付志達(dá),管玉龍. 血管加壓素研究進(jìn)展. 中國胸心血管外科臨床雜志, 2013, 20(1): 87-90. doi: 復(fù)制

版權(quán)信息: ?四川大學(xué)華西醫(yī)院華西期刊社《中國胸心血管外科臨床雜志》版權(quán)所有,未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

1.  Kounin G, Bashir Q. Mechanism and role of antidiuretic hormone. Surg Neurol, 2000, 53 (5):508-510.
2.  Oliver G, Schäfer EA. On the physiological action of extracts of pituitary body and certain other glandular organs:preliminary communication. J Physiol, 1895, 18 (3):277-279.
3.  Kumar S, Berl T. Vasopressin antagonists in the treatment of water-retaining disorders. Semin Nephrol, 2008, 28 (3):279-288.
4.  Ali F, Guglin M, Vaitkevicius P, et al. Therapeutic potential of vasopressin receptor antagonists. Drugs, 2007, 67 (6):847-858.
5.  Habib S, Boyer TD. Vasopressin V2-receptor antagonists in patients with cirrhosis, ascites and hyponatremia. Therap Adv Gastroenterol, 2012, 5 (3):189-197.
6.  Lemmens-Gruber R, Kamyar M. Vasopressin antagonists. Cell Mol Life Sci, 2006, 63 (15):1766-1779.
7.  Malay MB, Ashton RC Jr, Landry DW, et al. Low-dose vasopressin  in the treatment of vasodilatory septic shock. J Trauma, 1999, 47 (4):699-703.
8.  Gordon AC, Wang N, Walley KR, et al. The cardiopulmonary  effects of vasopressin compared with norepinephrine in septic shock. Chest, 2012, 142 (3):593-605.
9.  Carroll TG, Dimas VV, Raymond TT. Vasopressin rescue for in-pediatric intensive care unit cardiopulmonary arrest refractory to initial epinephrine dosing:a prospective feasibility pilot trial. Pediatr Crit Care Med, 2012, 13 (3):265-272.
10.  Stadlbauer KH, Wagner-Berger HG, Wenzel V, et al. Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation  with a combination of vasopressin and epinephrine in pigs. Anesth Analg, 2003, 96 (6):1743-1749.
11.  Jochberger S, Velik-Salchner C, Mayr VD, et al. The vasopressin and copeptin response in patients with vasodilatory shock after cardiac  surgery:a prospective, controlled study. Intensive Care Med, 2009, 35 (3):489-497.
12.  Argenziano M, Chen JM, Choudhri AF, et al. Management of vasodilatory shock after cardiac surgery:identification of predisposing factors and use of a novel pressor agent. J Thorac Cardiovasc Surg, 1998, 116 (6):973-980.
13.  Dünser MW, Mayr AJ, Stallinger A, et al. Cardiac performance during vasopressin infusion in postcardiotomy shock. Intensive Care Med, 2002, 28 (6):746-751.
14.  Bomberg H, Bierbach B, Flache S, et al. Endothelin and vasopressin influence splanchnic blood flow distribution during and after cardiopulmonary bypass. J Thorac Cardiovasc Surg, 2013, 145 (2):539-547.
15.  Khan TA, Bianchi C, Ruel M, et al. Differential effects on the mesenteric microcirculatory response to vasopressin and phenylephrine after cardiopulmonary bypass. J Thorac Cardiovasc Surg, 2007, 133 (3):682-688.
16.  Nagamine Y, Hara M. Intravenous arginine vasopressin for two pediatric cases of pulmonary hypertension after congenital heart surgery. Masui, 2012, 61 (10):1112-1116.
17.  Alten JA, Borasino S, Toms R, et al. Early initiation of arginine vasopressin infusion in neonates after complex cardiac surgery. Pediatr Crit Care Med, 2012, 13 (3):300-304.
18.  Mastropietro CW. Arginine vasopressin in neonates after surgery for congenital heart disease:right from the start? Pediatr Crit Care Med, 2012, 13 (3):360-361.
19.  Weiner GM, Niermeyer S. Medications in neonatal resuscitation:epinephrine and the search for better alternative strategies. Clin Perinatol, 2012, 39 (4):843-855.
20.  Jerath N, Frndova H, Mccrindle BW, et al. Clinical impact of vasopressin infusion on hemodynamics, liver and renal function in pediatric patients. Intensive Care Med, 2008, 34 (7):1274-1280.
21.  Cheung DC, Gill RS, Liu JQ, et al. Vasopressin improves systemic hemodynamics without compromising mesenteric perfusion in the resuscitation of asphyxiated newborn piglets:a dose-response study. Intensive Care Med, 2012, 38 (3):491-498.
22.  Narayen G, Mandal SN. Vasopressin receptor antagonists and their role in clinical medicine. Indian J Endocrinol Metab, 2012, 16 (2):183-191.
  1. 1.  Kounin G, Bashir Q. Mechanism and role of antidiuretic hormone. Surg Neurol, 2000, 53 (5):508-510.
  2. 2.  Oliver G, Schäfer EA. On the physiological action of extracts of pituitary body and certain other glandular organs:preliminary communication. J Physiol, 1895, 18 (3):277-279.
  3. 3.  Kumar S, Berl T. Vasopressin antagonists in the treatment of water-retaining disorders. Semin Nephrol, 2008, 28 (3):279-288.
  4. 4.  Ali F, Guglin M, Vaitkevicius P, et al. Therapeutic potential of vasopressin receptor antagonists. Drugs, 2007, 67 (6):847-858.
  5. 5.  Habib S, Boyer TD. Vasopressin V2-receptor antagonists in patients with cirrhosis, ascites and hyponatremia. Therap Adv Gastroenterol, 2012, 5 (3):189-197.
  6. 6.  Lemmens-Gruber R, Kamyar M. Vasopressin antagonists. Cell Mol Life Sci, 2006, 63 (15):1766-1779.
  7. 7.  Malay MB, Ashton RC Jr, Landry DW, et al. Low-dose vasopressin  in the treatment of vasodilatory septic shock. J Trauma, 1999, 47 (4):699-703.
  8. 8.  Gordon AC, Wang N, Walley KR, et al. The cardiopulmonary  effects of vasopressin compared with norepinephrine in septic shock. Chest, 2012, 142 (3):593-605.
  9. 9.  Carroll TG, Dimas VV, Raymond TT. Vasopressin rescue for in-pediatric intensive care unit cardiopulmonary arrest refractory to initial epinephrine dosing:a prospective feasibility pilot trial. Pediatr Crit Care Med, 2012, 13 (3):265-272.
  10. 10.  Stadlbauer KH, Wagner-Berger HG, Wenzel V, et al. Survival with full neurologic recovery after prolonged cardiopulmonary resuscitation  with a combination of vasopressin and epinephrine in pigs. Anesth Analg, 2003, 96 (6):1743-1749.
  11. 11.  Jochberger S, Velik-Salchner C, Mayr VD, et al. The vasopressin and copeptin response in patients with vasodilatory shock after cardiac  surgery:a prospective, controlled study. Intensive Care Med, 2009, 35 (3):489-497.
  12. 12.  Argenziano M, Chen JM, Choudhri AF, et al. Management of vasodilatory shock after cardiac surgery:identification of predisposing factors and use of a novel pressor agent. J Thorac Cardiovasc Surg, 1998, 116 (6):973-980.
  13. 13.  Dünser MW, Mayr AJ, Stallinger A, et al. Cardiac performance during vasopressin infusion in postcardiotomy shock. Intensive Care Med, 2002, 28 (6):746-751.
  14. 14.  Bomberg H, Bierbach B, Flache S, et al. Endothelin and vasopressin influence splanchnic blood flow distribution during and after cardiopulmonary bypass. J Thorac Cardiovasc Surg, 2013, 145 (2):539-547.
  15. 15.  Khan TA, Bianchi C, Ruel M, et al. Differential effects on the mesenteric microcirculatory response to vasopressin and phenylephrine after cardiopulmonary bypass. J Thorac Cardiovasc Surg, 2007, 133 (3):682-688.
  16. 16.  Nagamine Y, Hara M. Intravenous arginine vasopressin for two pediatric cases of pulmonary hypertension after congenital heart surgery. Masui, 2012, 61 (10):1112-1116.
  17. 17.  Alten JA, Borasino S, Toms R, et al. Early initiation of arginine vasopressin infusion in neonates after complex cardiac surgery. Pediatr Crit Care Med, 2012, 13 (3):300-304.
  18. 18.  Mastropietro CW. Arginine vasopressin in neonates after surgery for congenital heart disease:right from the start? Pediatr Crit Care Med, 2012, 13 (3):360-361.
  19. 19.  Weiner GM, Niermeyer S. Medications in neonatal resuscitation:epinephrine and the search for better alternative strategies. Clin Perinatol, 2012, 39 (4):843-855.
  20. 20.  Jerath N, Frndova H, Mccrindle BW, et al. Clinical impact of vasopressin infusion on hemodynamics, liver and renal function in pediatric patients. Intensive Care Med, 2008, 34 (7):1274-1280.
  21. 21.  Cheung DC, Gill RS, Liu JQ, et al. Vasopressin improves systemic hemodynamics without compromising mesenteric perfusion in the resuscitation of asphyxiated newborn piglets:a dose-response study. Intensive Care Med, 2012, 38 (3):491-498.
  22. 22.  Narayen G, Mandal SN. Vasopressin receptor antagonists and their role in clinical medicine. Indian J Endocrinol Metab, 2012, 16 (2):183-191.