目的 探討支氣管哮喘患者血清中8-異前列腺素( 8-iso-PG) 水平檢測的臨床意義。方法 選取2009 年2 月至8 月就診于昆明醫(yī)學(xué)院第二附屬醫(yī)院呼吸內(nèi)科的18 例哮喘急性發(fā)作期患者為哮喘組, 經(jīng)治療后達緩解期。選取2009 年8 月來自昆明醫(yī)學(xué)院第二附屬醫(yī)院的職工體檢志愿者20 例為健康對照組。測定所有研究對象血清中8-iso-PG 水平及肺功能指標FEV1% pred。結(jié)果 哮喘患者急性發(fā)作期血清中8-iso-PG 水平均高于緩解期和健康對照組[ ( 157. 46 ±46. 99) pg/mL 比( 43. 52 ±13. 62) pg/mL和( 15. 23 ±1. 96) pg/mL, P lt;0. 01] , 緩解期哮喘患者血清中8-iso-PG 水平也高于健康對照組( P lt;0. 01) 。哮喘患者急性發(fā)作期血清中8-iso-PG 水平與FEV1% pred 呈負相關(guān)( r =- 0. 533, P lt;0. 05) 。結(jié)論 8-iso-PG 作為氧化應(yīng)激反應(yīng)的標記物參與了哮喘的發(fā)病, 通過監(jiān)測其在哮喘患者血清中的水平可以反映哮喘患者體內(nèi)氧化應(yīng)激反應(yīng)狀態(tài), 可以作為一種評估哮喘患者病情嚴重程度及隨訪治療效果的指標。
引用本文： 李永霞,陳敏,鐘紅,海冰. 支氣管哮喘患者血清中8-異前列腺素水平研究. 中國呼吸與危重監(jiān)護雜志, 2010, 9(6): 598-601. doi: 復(fù)制
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| 1. | Montuschi P, Kharitonov SA, Ciabattoni G, et al. Exhaled 8 -isoprostane as a new non-invasive biomarker of oxidative stress in Cystic fibrosis. Thorax, 2000, 55: 205-209. |
| 2. | Janssen LJ. Isoprostanes: an overview and putative roles in pulmonary pathophysiology. Am J Physiol Lung Cell Mol Physiol,2001, 280: L1067 -L1082. |
| 3. | 中華醫(yī)學(xué)會呼吸病學(xué)分會哮喘學(xué)組. 支氣管哮喘防治指南( 支氣管哮喘的定義、診斷、治療和管理方案) . 中華結(jié)核和呼吸雜志, 2008, 31: 177-185. |
| 4. | Montuschi P, Barnes PJ, Roberts LJ 2nd, et al. Isoprostane: markers and mediators of oxidative stress. FASEB J, 2004, 18: 1791 -1800 . |
| 5. | Helmersson J, Basu S. F2-isoprostane excretion rate and diurnal variation in human urine. Prostaglandins Leukot Essent Fatty Acids,2004, 61: 203. |
| 6. | Kirschvink N, Martin N, Fievez L, et al. Airway inflammation in cadmium exposed rats is associated with pulmonary oxidative stress and emphysema. Free Radical Research, 2006, 40 : 241-250 . |
| 7. | Caramori G, Papi A. Oxidants and asthma. Thorax, 2004, 59: 170 -173 . |
| 8. | Nadeem A, Raj HG, Chhabra SK. Increased oxidative stress in acute exacerbations of asthma. J Asthma, 2005 , 42: 42-45. |
| 9. | 于進洪, 李軍濤, 李國翔, 等. COPD 急性加重期患者血清8 -isoprostane 水平與肺功能和動脈氧分壓的關(guān)系. 山東醫(yī)藥,2008, 48: 64-65 . |
| 10. | Li Yongxia, Chongsuvivatwong V, Geater A, et al. Are biomarker levels a good follow-up tool for evaluating obstructive sleep apnea syndrome treatments? Respiration, 2008, 76: 317-323 . |
| 11. | Li Yongxia, Chongsuvivatwong V, Geater A, et al. Exhaled breath condensate cytokine level as a diagnostic tool for obstructive sleep apnea syndrome. Sleep Med, 2009, 10: 95 -103. |
| 12. | Zhao JJ, Shimizu Y, Dobashi K, et al. The Relationship Between Oxidative Stress and Acid Stress in Adult Patients With Mild Asthma. J Investing Clin Immunol, 2008 , 18: 41-45. |
| 13. | Montuschi P, Barnes PJ. Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol, 2002, 109 : 615-620. |
| 14. | 劉翱, 李少瑩, 楊偉康, 等. 支氣管哮喘患者呼出氣冷凝液中8 -異前列腺素的研究. 中國呼吸與危重監(jiān)護雜志, 2009 , 8, 337 -340. |
- 1. Montuschi P, Kharitonov SA, Ciabattoni G, et al. Exhaled 8 -isoprostane as a new non-invasive biomarker of oxidative stress in Cystic fibrosis. Thorax, 2000, 55: 205-209.
- 2. Janssen LJ. Isoprostanes: an overview and putative roles in pulmonary pathophysiology. Am J Physiol Lung Cell Mol Physiol,2001, 280: L1067 -L1082.
- 3. 中華醫(yī)學(xué)會呼吸病學(xué)分會哮喘學(xué)組. 支氣管哮喘防治指南( 支氣管哮喘的定義、診斷、治療和管理方案) . 中華結(jié)核和呼吸雜志, 2008, 31: 177-185.
- 4. Montuschi P, Barnes PJ, Roberts LJ 2nd, et al. Isoprostane: markers and mediators of oxidative stress. FASEB J, 2004, 18: 1791 -1800 .
- 5. Helmersson J, Basu S. F2-isoprostane excretion rate and diurnal variation in human urine. Prostaglandins Leukot Essent Fatty Acids,2004, 61: 203.
- 6. Kirschvink N, Martin N, Fievez L, et al. Airway inflammation in cadmium exposed rats is associated with pulmonary oxidative stress and emphysema. Free Radical Research, 2006, 40 : 241-250 .
- 7. Caramori G, Papi A. Oxidants and asthma. Thorax, 2004, 59: 170 -173 .
- 8. Nadeem A, Raj HG, Chhabra SK. Increased oxidative stress in acute exacerbations of asthma. J Asthma, 2005 , 42: 42-45.
- 9. 于進洪, 李軍濤, 李國翔, 等. COPD 急性加重期患者血清8 -isoprostane 水平與肺功能和動脈氧分壓的關(guān)系. 山東醫(yī)藥,2008, 48: 64-65 .
- 10. Li Yongxia, Chongsuvivatwong V, Geater A, et al. Are biomarker levels a good follow-up tool for evaluating obstructive sleep apnea syndrome treatments? Respiration, 2008, 76: 317-323 .
- 11. Li Yongxia, Chongsuvivatwong V, Geater A, et al. Exhaled breath condensate cytokine level as a diagnostic tool for obstructive sleep apnea syndrome. Sleep Med, 2009, 10: 95 -103.
- 12. Zhao JJ, Shimizu Y, Dobashi K, et al. The Relationship Between Oxidative Stress and Acid Stress in Adult Patients With Mild Asthma. J Investing Clin Immunol, 2008 , 18: 41-45.
- 13. Montuschi P, Barnes PJ. Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol, 2002, 109 : 615-620.
- 14. 劉翱, 李少瑩, 楊偉康, 等. 支氣管哮喘患者呼出氣冷凝液中8 -異前列腺素的研究. 中國呼吸與危重監(jiān)護雜志, 2009 , 8, 337 -340.