• 南京市胸科醫(yī)院呼吸科( 江蘇南京 210029);

目的  探討肺癌患者血清生長激素釋放肽和瘦素水平的變化及意義。方法  應用放射免疫分析法和酶聯(lián)免疫吸附法( ELISA) 測定46 例肺癌患者血清中生長激素釋放肽和瘦素水平的變化, 并與30 例正常健康人作比較。結果  肺癌患者血清生長激素釋放肽和瘦素水平均高于正常人( P  lt;0. 01) , 且兩者呈正相關性。結論  檢測肺癌患者血清生長激素釋放肽和瘦素水平的變化對疾病的監(jiān)測具有重要的臨床價值。

引用本文： 徐春華,于力克,張宇. 肺癌患者血清生長激素釋放肽和瘦素的水平變化及意義. 中國呼吸與危重監(jiān)護雜志, 2010, 9(5): 537-538. doi: 復制

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1. Kojima M, Hosoda H, Date Y, et al. Ghrelinis agrowth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660 .
2. Wallace AM, Sattar N, McMillan DC. Efect ofweight loss and the inflammatory response Oil leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res, 1998, 4 : 2977-2979.
3. 任珂明, 厲有名. Ghrelin 及其受體在腫瘤發(fā)生中的作用. 國外醫(yī)學· 老年醫(yī)學分冊, 2006, 27 : 196-200.
4. Vivenza D, Rapa A, Castellino N, et al. Ghrelin gone polymorphisms and ghrelin, insulin, IGF-1 , leptin and anthmpometric data in children and adolescents. Eur J Endocrinol, 2004, 151: 127 -133.
5. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660.
6. Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 2002, 51: 124 -129.
7. Smith RG, Van der Ploeg LH, Howard AD, et al. Peptidomimetic regulation ofgrowth hormone secretion. Endocr Rev, 1997, 18: 621 -645.
8. Mckee KK, Palyha OC, Feiner SD, et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.Mol Endocrino1, 1997, 11 : 415-423.
9. Shuto Y, Shibasaki T, Wada K, et al. Generation of polyclonal antiserumagainst the growth hormone secretagogue receptor( GHSR): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach ofrats. Life Sci, 2001, 68: 991 -996.
10. Cassoni P, Allia E, Marrocco T, et al. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line. J Endocrinol Invest, 2006, 29: 781 -790.
11. Shimizu Y, Nagaya N, Isobe T, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res, 2003 , 9: 774-778 .
12. Maninez V, Barrachlna MD, Wang L, et al. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats.Neumreport, 1999, 10: 3217-3221.
  1. 1. Kojima M, Hosoda H, Date Y, et al. Ghrelinis agrowth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660 .
  2. 2. Wallace AM, Sattar N, McMillan DC. Efect ofweight loss and the inflammatory response Oil leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res, 1998, 4 : 2977-2979.
  3. 3. 任珂明, 厲有名. Ghrelin 及其受體在腫瘤發(fā)生中的作用. 國外醫(yī)學· 老年醫(yī)學分冊, 2006, 27 : 196-200.
  4. 4. Vivenza D, Rapa A, Castellino N, et al. Ghrelin gone polymorphisms and ghrelin, insulin, IGF-1 , leptin and anthmpometric data in children and adolescents. Eur J Endocrinol, 2004, 151: 127 -133.
  5. 5. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660.
  6. 6. Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 2002, 51: 124 -129.
  7. 7. Smith RG, Van der Ploeg LH, Howard AD, et al. Peptidomimetic regulation ofgrowth hormone secretion. Endocr Rev, 1997, 18: 621 -645.
  8. 8. Mckee KK, Palyha OC, Feiner SD, et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.Mol Endocrino1, 1997, 11 : 415-423.
  9. 9. Shuto Y, Shibasaki T, Wada K, et al. Generation of polyclonal antiserumagainst the growth hormone secretagogue receptor( GHSR): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach ofrats. Life Sci, 2001, 68: 991 -996.
  10. 10. Cassoni P, Allia E, Marrocco T, et al. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line. J Endocrinol Invest, 2006, 29: 781 -790.
  11. 11. Shimizu Y, Nagaya N, Isobe T, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res, 2003 , 9: 774-778 .
  12. 12. Maninez V, Barrachlna MD, Wang L, et al. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats.Neumreport, 1999, 10: 3217-3221.