目的 討89Sr治療肺癌多發(fā)骨轉(zhuǎn)移的臨床療效。方法 30例肺癌多發(fā)骨轉(zhuǎn)移患者予以肘靜脈注射89SrCl2 148 MBq/例次，治療后第28 d，觀察疼痛強(qiáng)度（通過劃線法和止痛藥的使用情況評價(jià)），通過同位素全身骨掃描骨轉(zhuǎn)移灶數(shù)目、尿吡啶酚（PYD）和脫氧吡啶酚（DPD）水平的變化進(jìn)行療效評價(jià)。結(jié)果 與治療前比較，治療28 d后疼痛強(qiáng)度顯著緩解(P lt;0.001)，疼痛緩解率73.3%，消失率16.6%。骨轉(zhuǎn)移灶數(shù)目減少16例，有效率53.3%，改善程度明顯（P lt;0.001）。PYD和DPD較治療前明顯下降[（62.48±37.25）比（100.15±48.65）nmol/mmol Cr，（13.94±8.66）比（31.25±15.32）nmol/mmol Cr，P均 lt;0.001]。結(jié)論 89Sr可有效緩解肺癌多發(fā)骨轉(zhuǎn)移的骨痛，減少骨轉(zhuǎn)移灶數(shù)量，提高患者生活質(zhì)量。
引用本文： 胥杰,陳曉. 89Sr治療30例肺癌多發(fā)骨轉(zhuǎn)移的療效觀察. 中國呼吸與危重監(jiān)護(hù)雜志, 2008, 08(2): 104-106. doi: 復(fù)制
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- 1. Ashayeri E,Omogbehin A,Sridhar R,et al.Strontium 89 in the treatment of pain due to diffuse osseous metastases:a university hospital experience.J Natl Med Assoc,2002,94:706-711.
- 2. 郭永忠,張峰.尿脫氧吡啶酚是新的骨吸收生化指標(biāo).醫(yī)學(xué)綜述,2000,6:7-9.
- 3. Finlay IG,Mason MD,Shelley M.Radioisotopes for the palliation of metastatic bone cancer:a systematic review.Lancet Oncol,2005,6:392-400.
- 4. Ron IG,Stav O,Vishne T,et al.The correlation between palliation of bone pain by intravenous strontium-89 and external beam radiation to linked field in patients with osteoblastic bone metastases.Am J Clin Oncol,2004,27:500-504.
- 5. Lam MG,de Klerk JM,van Rijk PP,et al.Bone seeking radiopharmaceuticals for palliation of pain in cancer patients with osseous metastases.Anticancer Agents Med Chem,2007,7:381-397.