用犬制作膽道梗阻模型，觀察梗阻后不同時相犬十二指腸和回盲部需氧菌的變化，并對其腸壁進(jìn)行組織學(xué)與超微結(jié)構(gòu)觀察，以探討膽道梗阻對小腸菌群的影響和腸道菌群在膽道感染等內(nèi)源性感染中的作用。結(jié)果顯示：隨犬膽道梗阻時間的延長，小腸菌群發(fā)生不同程度的變化，表現(xiàn)為細(xì)菌的輕度增殖，定殖菌種數(shù)增多，下段小腸細(xì)菌（主要是大腸桿菌）移位到十二指腸，使十二指腸內(nèi)總需氧菌和大腸桿菌的定殖率明顯增高；回腸粘膜充血水腫、炎細(xì)胞浸潤、上皮微絨毛減少。破環(huán)等病理改變。由此表明，膽道梗阻時腸菌失調(diào)和腸粘膜屏障的破環(huán)可能與膽道梗阻時膽道感染發(fā)生率高有著密切關(guān)系。因此臨床上在及時解除膽道梗阻的同時，還應(yīng)注意調(diào)整膽道梗阻患者的腸道菌群平衡，阻止下消化道細(xì)菌上行定植，以防止腸源性感染的發(fā)生。
引用本文： 江藝,吳愛平. 膽道梗阻對犬小腸菌群的影響. 中國普外基礎(chǔ)與臨床雜志, 1995, 2(3): 132-135. doi: 復(fù)制
版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編
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