• 1.浙江醫(yī)科大學(xué)附屬第一醫(yī)院普外科(杭州 310003)2.腫瘤科3.中心實(shí)驗(yàn)室;

采用酶偶聯(lián)比色法測定47例(103例次)阻塞性黃疸(阻黃)和53例(83例次)無黃疸單純膽囊結(jié)石患者血清總膽酸(TCA)的水平,并探討其與黃疸程度及肝細(xì)胞損害的關(guān)系。結(jié)果表明:阻黃組TCA明顯高于無黃疸組(P<0.001),與血清總膽紅素、直接膽紅素、谷丙轉(zhuǎn)氨酶均有正相關(guān)關(guān)系。說明TCA水平不僅與黃疸程度有關(guān),而且與肝細(xì)胞受損狀況有關(guān)。單項(xiàng)檢測TCA對阻黃診斷的敏感性和特異性分別為69.9%。和71.1%,與單項(xiàng)檢測堿性磷酸酶的敏感性(79.6%)和特異性(69.9%)相近。聯(lián)合檢測二者并不能提高對阻黃診斷的特異性(56.6%)。

引用本文: 梁廷波,鄭樹森,盛建明,楊榮偉. 梗阻性黃疸患者血清總膽酸測定的臨床意義. 中國普外基礎(chǔ)與臨床雜志, 1996, 3(2): 88-89. doi: 復(fù)制

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  1. 1. Washizu T,Ishida T,Washizu M,et al.Changes in bile acid composition of serum and gallbladder in bile duct ligated dogs.J Vet Med Sci,1994;56(2):299.
  2. 2. Demers LM,Hepner GW.Levels of immunoreactive glycojugated bile acid in health and heaptobiliary disease.Am J Clin Path,1976;66:832.
  3. 3. 劉樹業(yè),宋繼昌,聶福華等.肝病患者血清與膽汁中7種結(jié)合膽酸的高效液相色譜分析.中華醫(yī)學(xué)檢驗(yàn)雜志,1993;(3):152.
  4. 4. 李冰,沈魁.梗阻性黃疸患者膽汁引流前后膽酸代謝的變化.中華實(shí)驗(yàn)外科雜志,1992;9(1):46.