為了探討增加細(xì)胞內(nèi)糖原含量能否改善肝臟缺血再灌注損傷程度，本實(shí)驗(yàn)對(duì)3組糖原含量顯著不同的兔肝臟缺血再灌注過程中的組織形態(tài)學(xué)、肝臟酶學(xué)、組織ATP含量、細(xì)胞膜Ca2+-ATP酶活性及胞漿內(nèi)游離Ca2+濃度進(jìn)行了觀察。結(jié)果： 糖原含量高的肝臟，其細(xì)胞能量代謝旺盛，細(xì)胞膜Ca2+-ATP酶活性強(qiáng)，胞漿內(nèi)游離Ca2+濃度相對(duì)穩(wěn)定，組織結(jié)構(gòu)及功能損傷輕。本實(shí)驗(yàn)結(jié)果提示： 缺血前增加肝臟糖原含量可顯著地拮抗肝臟缺血再灌注損傷。
引用本文： 湯禮軍,田伏洲,王雨,李曉軍,尹致良. 肝細(xì)胞糖原拮抗肝臟缺血再灌注損傷及其相關(guān)機(jī)理的研究. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(4): 196-198. doi: 復(fù)制
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