• 1.山東威海市立醫(yī)院普外科（威海264200）;;
  • 2.白求恩醫(yī)科大學第二臨床醫(yī)學院普外科（長春130041）;

目的  探討p16、Rb蛋白在甲狀腺癌發(fā)生、發(fā)展中的作用及其相互關系。方法  采用免疫組織化學SP法對46例甲狀腺癌中p16、Rb蛋白表達情況進行檢測。結果  在甲狀腺癌中，p16蛋白的表達隨腫瘤的惡性程度增高而降低，與淋巴結轉移、臨床分期及預后指數(shù)呈負相關。Rb蛋白在各型甲狀腺癌中均呈陽性表達，p16、Rb表達無相關性。結論  p16基因的異常表達在甲狀腺癌的發(fā)生、發(fā)展中有一定作用，而Rb基因可能無作用。

引用本文： 王子良,王農(nóng),耿建利,戰(zhàn)智勇,王太澤. 抑癌基因p16、Rb在甲狀腺癌組織中的表達. 中國普外基礎與臨床雜志, 2001, 8(5): 319-321. doi: 復制

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  2. 2. Fromowitz FB, Viola MV, Chao S, et al. Res p21 expression in the progression of breast cancer 〔Ｊ〕. Human Pathol, 1987; 18(12)∶1268.
  3. 3. 王翠芳，騰猛，李迎旭等. p16蛋白在甲狀腺癌的表達或缺失的意義 〔Ｊ〕. 中國腫瘤臨床， 1998； 25（3）∶221.
  4. 4. Serano M, Hannon GJ, Becach D. A new regulatory motif in cellcycle control causing specific inhibition of cyclin D/CDK4 〔Ｊ〕. Nature, 1993; 336(6456)∶704.
  5. 5. Kamb A, Gruis NA, WeaverFeldhaus J, et al. A cell cycle regulator potentially involved in genesis of many tumor types 〔Ｊ〕. Science, 1994; 264(5157)∶436.
  6. 6. Zou MU, Shi YE, Farid NR. Retinoblastoma gene defects are control to thyroid carcinogenesis 〔C〕. Endocrine Society Meeting, 1993∶91-4.
  7. 7. Holm R, Nesland JM. Retinoblastoma and p53 tumor suppressor gene protein expression in carcinomas of the thyroid gland 〔Ｊ〕. J Pathol, 1994; 172(3)∶267.
  8. 8. Xu HJ, Hu SX, Cagle PT, et al. Absence of retinoblastoma protein in primary nonsmallcell lung carcinomas 〔Ｊ〕. Cancer Res, 1991; 51(10)∶ 2735.