目的 研究早期胃癌MiB-1表達(dá)與臨床病理的關(guān)系。
方法 采用免疫組織化學(xué)法,對99例早期胃癌手術(shù)切除標(biāo)本進(jìn)行檢測。
結(jié)果 MiB-1增殖指數(shù)(MiB-1 PI)與患者年齡、腫瘤大小、部位及浸潤深度有關(guān)。分化型腺癌MiB-1 PI高于低分化腺癌(P<0.01); 胃壁淋巴管浸潤或淋巴結(jié)轉(zhuǎn)移陽性腫瘤的MiB-1 PI較高(P<0.05)。MiB-1增殖等級(MiB-1 PG)與患者術(shù)后生存率有關(guān),MiB-1 PGⅠ、Ⅱ級術(shù)后生存高于MiB-1 PG Ⅲ、Ⅳ級(P<0.05)。
結(jié)論 即使在胃癌早期,腫瘤的不同增殖水平亦與患者的預(yù)后直接相關(guān)。
引用本文: 車向明,王康,帆北修一,愛甲孝. MiB-1的表達(dá)與早期胃癌臨床病理及預(yù)后的關(guān)系. 中國普外基礎(chǔ)與臨床雜志, 2001, 8(3): 145-147. doi: 復(fù)制
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2. | Moul JW, Bettencourt MC, Sesterhern IA, et al. Protein expression of p53, bcl2 and Ki67 (MiB1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer 〔J〕. Surgery, 1996; 120(2)∶159. |
3. | Lam KY, Law SY, So MK, et al. Prognostic implication of proliferative markers MiB1 and PC10 in esophageal squamous cell carcinoma 〔J〕. Cancer, 1996; 77(1)∶7. |
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- 1. Key G, Becher MHG, Duchrow M, et al. New Ki67 equivalent murine monoclonal antibodies (MiB1) prepared against recombinant parts of the Ki67 antigen 〔J〕. Anal Cell Pathol, 1992; 4(2)∶181.
- 2. Moul JW, Bettencourt MC, Sesterhern IA, et al. Protein expression of p53, bcl2 and Ki67 (MiB1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer 〔J〕. Surgery, 1996; 120(2)∶159.
- 3. Lam KY, Law SY, So MK, et al. Prognostic implication of proliferative markers MiB1 and PC10 in esophageal squamous cell carcinoma 〔J〕. Cancer, 1996; 77(1)∶7.
- 4. Japanese research society for gastric cancer. The general rules for the gastric study 〔C〕. 12th endition. Tokyo. Kanehara & CO, LTD.1993∶1-53.
- 5. Muller W, Schneiders A, Meier S, et al. Immunohistochemical study on the prognosis value of MiB 1 in gastric carcinoma 〔J〕. Br J Cancer, 1996; 74(5)∶759.
- 6. Frank RE, Saclarides TJ, Leurgans S, et al. Tumor angiogenesis as a predicator of recurrence and survival in patients with nodenegative colon cancer 〔J〕. Anal Surg, 1995; 222(6)∶695.
- 7. Kimura H, Yonemura Y, Epstein AL. Flowcytometric quantitation of the proliferation associated nuclear antigen p105 and DNA content in advanced gastric cancer 〔J〕. Cancer, 1991; 68(12)∶2175.
- 8. Saitoh K, Chiba T, Nakamura K. Cell proliferation kinetics of human gastric carcinoma:an immunohistochemical study with a monoclonal antibody against DNA polymeraseα 〔J〕. Euro J Cancer, 1992; 28(10)∶1642.
- 9. 車向明,帆北修一,愛甲孝.70歲以上老年人早期胃癌的臨床病理特點(diǎn) 〔J〕.中國普通外科雜志,1997; 6(3)∶129.
- 10. 車向明,帆北修一,愛甲孝.早期胃癌的臨床病理特點(diǎn) 〔J〕.西安醫(yī)科大學(xué)學(xué)報(bào),1997; 8(2)∶15.
- 11. Kidama Y, Inoduchi K, Spejima K, et al. Growth patterns and prognosis in early gastric carcinoma superficially spreading and penetrating growth types 〔J〕. Cancer , 1983; 52(2)∶320.