• 四川大學(xué)華西醫(yī)院普外科（成都610041）;

目的探討β連環(huán)蛋白和結(jié)腸腺瘤性息肉病(APC)基因的分子結(jié)構(gòu)和功能特征以及其在腫瘤發(fā)生、發(fā)展中的作用。方法綜述近年來有關(guān)β連環(huán)蛋白和APC基因分子生物學(xué)以及與腫瘤學(xué)方面的研究。結(jié)果β連環(huán)蛋白和APC基因由于自身調(diào)節(jié)和相互調(diào)節(jié)異常，在腫瘤發(fā)生的早期表達(dá)異常增高，但與腫瘤的進(jìn)展、轉(zhuǎn)移關(guān)系似乎正相反。此外，β連環(huán)蛋白和APC基因還可以調(diào)節(jié)p53、cmyc基因以及細(xì)胞周期蛋白D1等因子表達(dá)。結(jié)論β連環(huán)蛋白和APC基因在多種腫瘤的發(fā)生、發(fā)展中可能起著中心作用，并與其它癌/抑癌基因和因子相互產(chǎn)生調(diào)節(jié)作用。

引用本文： 戴越盟,綜述,嚴(yán)律南,審校. β-連環(huán)蛋白及APC基因與腫瘤. 中國(guó)普外基礎(chǔ)與臨床雜志, 2002, 9(4): 291-292. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國(guó)普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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21. Kondo Y， Kanai Y， Sakamoto M， et al. betacatenin accumulation and mutation of exon 3 of the betacatenin gene in hepatocellular carcinoma [J]. Jpn J Cancer Res， 1999; 90(12)∶1301.
22. Damalas A，BenZe’ev A，Simcha I， et al. Excess betacatenin promotes accumulation of transcriptionally active p53 [J]. EMBO J， 1999; 18(11)∶3054.
23. Tetsu O，McCormick F. betacatenin regulates expression of cyclin D1 in colon carcinoma cells [J]. Nature， 1999; 398(6726)∶422.
  1. 1. Cox RT. Peifr M. Wingless signaling: the inconvenient complexities of life [J]. Curr Biol， 1998; 8(4)∶R140.
  2. 2. Behrens J，Jerchow BA，Wurtele M， et al. Function interaction of an axin homolog, conductin, with betacatenin, APC and GSK 3 beta [J]. Science， 1998; 280(5363)∶596.
  3. 3. Sparks AB，Morin PJ，Vogelstein B， et al. Mutational analysis of the APC/betacatenin/Tcf pathway in colorectal cancer [J]. Cancer Res，1998; 58(6)∶1130.
  4. 4. Hulsken J，Birchmeier W，Behrens J. Ecadherin and APC compete for the interaction with betacatenin and the cytoskeleton [J]. J Cell Biol， 1994; 127(6 Pt 2)∶2061.
  5. 5. de La Coste A，Romagnolo B，Billuart P， et al. Somatic mutation of the βcatenin gene are frequent in mouse and human hepatocellular carcinomas [J]. Proc Natl Acda Sci USA，1999; 95(15)∶8847.
  6. 6. Gumbiner BM. Cell adhesion: the molecular basis of tissue architecture and morphogenesis [J]. Cell，1996; 84(3)∶345.
  7. 7. Oyama T，Kanai Y，Ochiai A， et al. A truncated betacatenin disrupts the interaction between Ecadherin and alphacatenin: a cause of loss of intercellular adhesiveness in human cancer cell lines [J]. Cancer Res， 1994; 54(42)∶6282.
  8. 8. He X，SaintJeannet JP，Woodgett JR， et al. Glycogen synthase kinase3 and dorsoventral patterning in Xenopus embryos [J]. Nature， 1995; 374(6523)∶617.
  9. 9. Behrens J，von Kries JP，Kuhl M.et al. Functional interaction of betacatenin with the transcription factor LEF1 [J]. Nature， 1996; 382(6592)∶638.
  10. 10. Nakamura Y. The role of the adenomatous polyposis coli (APC) gene in human cancers [J]. Adv Cancer Res， 1993; 62∶65.
  11. 11. Matsumine A，Ogai A，Senda T， et al. Binding of APC to the human homolog of the Drosophila discs larger tumor suppressor protein [J]. Science， 1996; 272(5264)∶1020.
  12. 12. Gumbiner BM. Carcinogenesis: a balance between betacatenin and APC [J]. Curr Biol，1997; 7(7)∶R443.
  13. 13. Peifer M. Regulating cell proliferation: as easy as APC [J]. Science， 1996; 272(5264)∶974.
  14. 14. Pennisi E. How a growth control path takes a wrong turn to cancer [J]. Science， 1998; 281(5382)∶1438.
  15. 15. Kinzler KW，Vogelsein B. Lessons from hereditary colorectal cancer [J]. Cell， 1996; 87(2)∶159.
  16. 16. Sparks AB，Morin PJ，Vogelstein B， et al. Mutation al analysis of the APC/betacatenin/Tcf pathway in colorectal cancer [J]. Cancer Res， 1998; 58(6)∶1130.
  17. 17. Devereux TR，Anna CH，F(xiàn)oley JF， et al. Mutation of betacatenin is an early event in chemically induced mouse hepatocellular carcinogenesis [J]. Oncogene， 1999; 18(33)∶4726.
  18. 18. B`ankfalvi A，Terpe HJ，Breukelmann D， et al. Immunophenotypic and prognostic analysis of Ecadherin and betacatenin expression during breast carcinogenesis and tumour progression: a comparative study with CD44. Histopathology， 1999; 34(1)∶25.
  19. 19. Takayama T，Shiozaki H，Shibamoto S， et al. Betacatenin expression in human cancers [J]. Am J Pathol， 1996; 148(1)∶39.
  20. 20. Akimoto T，Kawabe S，Grothey A， et al. Low Ecadherin and betacatenin expression correlates with increased spontaneous and artificial lung metastases of murine carcinomas [J]. Clin Exp Metastasis， 1999; 17(2)∶171.
  21. 21. Kondo Y， Kanai Y， Sakamoto M， et al. betacatenin accumulation and mutation of exon 3 of the betacatenin gene in hepatocellular carcinoma [J]. Jpn J Cancer Res， 1999; 90(12)∶1301.
  22. 22. Damalas A，BenZe’ev A，Simcha I， et al. Excess betacatenin promotes accumulation of transcriptionally active p53 [J]. EMBO J， 1999; 18(11)∶3054.
  23. 23. Tetsu O，McCormick F. betacatenin regulates expression of cyclin D1 in colon carcinoma cells [J]. Nature， 1999; 398(6726)∶422.