• 四川大學華西醫(yī)院普外科（成都610041）;

目的探討膽囊膽固醇結石患者脂質代謝變化及其在膽石成因中的地位和作用。方法檢測161例膽囊膽固醇結石患者及94例非結石病患者的血脂和載脂蛋白（apolipoprotein,Apo）。結果膽石組甘油三酯(TG)和載脂蛋白CⅡ（Apo CⅡ）及載脂蛋白CⅢ（Apo CⅢ）水平明顯高于對照組，而總膽固醇（TC）、高密度脂蛋白膽固醇（HDLc）及其亞組分和低密度脂蛋白膽固醇（LDLc）明顯低于對照組（P＜0.01或P＜0.05）； 載脂蛋白AⅡ（Apo AⅡ）、載脂蛋白B100（Apo B100）及載脂蛋白E（Apo E）比對照組升高，載脂蛋白AⅠ（Apo AⅠ）比對照組低，但差異無顯著性意義（P gt;0.05）。結論TG、Apo CⅡ及Apo CⅢ水平的升高和TC、LDLc、HDLc及其亞組分水平的降低，是膽固醇結石患者脂質代謝的重要特征，也可能是膽石形成的重要原因。

引用本文： 姚有貴,李寧,林琦遠,程南生,肖路加. 膽囊膽固醇結石患者血脂和載脂蛋白水平的觀察. 中國普外基礎與臨床雜志, 2002, 9(3): 186-188. doi: 復制

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10. Kibe A, Holzbach RT, LaRusso NT, et al. Inhibition of cholesterol crytal formation by apolipoprotein AI and AII in model systems of supersaturated bile: implication a for gallstones pathogenesis in man [J]. Science，1984; 225（3）∶514.
11. Bravo E. Hepatic uptake and processing of free cholesterol from different lipoproteins with and without sodium taurocholate administration, an in vivo study in the rat [J]. Biolchem Biophys Acta，1990; 74（5）∶1045.
12. 付賢波，宮軻，邵曉明，等. 血清脂質、載脂蛋白與膽汁類脂水平及膽囊結石類型的關系 \[J\]. 中華醫(yī)學雜志，1995;75(11)∶656.
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  1. 1. Mohr GC, KritzSilverstein D,BarrettConnor E. Plasma lipids and gallbladder disease [J]. Am J Epidemiol，1991; 134(1)∶78.
  2. 2. Admirand WH. The physicochemical basis of cholesterol gallstone formation in man [J]. J Clin Invest，1968; 17(5)∶1043.
  3. 3. Harvey RRC. Will the real cholesterolnucleating and antinucleating proteins please stand up [J]? Gastroenterology，1993; 104(4)∶646.
  4. 4. Breslow JL. Apolipoprotein genetic variation and human disease \[M\]. Physiol Rev，1988∶68-85.
  5. 5. Zannis VI，Breslow JL. Genetic mutations affecting human lipoprotein metabolism [J]. Adv Hum Genet，1985; 14（1）∶125.
  6. 6. Alvaro D, Angelico F, Attili AF, et al. Plasma lipid lipoproteins and biliary lipid composition in female gallstone patients [J]. Biomed Biochem Acta，1986; 45（5）∶761.
  7. 7. Thijs C, Knipschild P, Brombacher P, et al. Serum lipids and gallstones, a casecontrol study [J]. Gastroenterology，1990; 99（6）∶843.
  8. 8. Hoeg JM, Meng MS, Ronan R, et al. Human apolipoprotein AI [J]. J Biochem，1986; 261（8）∶3911.
  9. 9. Mahley RW, Innerarity TL, Rall SC, et al. Plasma lipoproteins:apolipoprotein structure and function [J]. J Lipid Res，1984; 25（11）∶1277.
  10. 10. Kibe A, Holzbach RT, LaRusso NT, et al. Inhibition of cholesterol crytal formation by apolipoprotein AI and AII in model systems of supersaturated bile: implication a for gallstones pathogenesis in man [J]. Science，1984; 225（3）∶514.
  11. 11. Bravo E. Hepatic uptake and processing of free cholesterol from different lipoproteins with and without sodium taurocholate administration, an in vivo study in the rat [J]. Biolchem Biophys Acta，1990; 74（5）∶1045.
  12. 12. 付賢波，宮軻，邵曉明，等. 血清脂質、載脂蛋白與膽汁類脂水平及膽囊結石類型的關系 \[J\]. 中華醫(yī)學雜志，1995;75(11)∶656.
  13. 13. Gylling H, Kontula K, Miettinen TA,et al. Cholesterol absorption and metabolism and LDL kinetics in healthy men with different apolipoprotein E phenotypes and apolipoprotein B Xba I and LDL receptor Pvu II genotypes [J]. Arterioscler Thromb Vasc Biol，1995; 15（2）∶208.