• 第三軍醫(yī)大學(xué)附屬西南醫(yī)院病理研究所（重慶400038）;

目的 探討腫瘤相關(guān)抗原表達(dá)對(duì)膽囊癌早期診斷及其預(yù)后判斷的價(jià)值。方法采用免疫組化染色對(duì)10例慢性膽囊炎、10例膽囊腺瘤及50例膽囊癌組織的癌胚抗原（CEA）、癌相關(guān)粘液抗原（CA50）、鈣粘附蛋白E（ECD）及增殖細(xì)胞核抗原（PCNA）的表達(dá)進(jìn)行檢測(cè)。 結(jié)果膽囊癌組織中CEA及CA50表達(dá)陽(yáng)性率顯著高于腺瘤組和膽囊炎組（P＜0.05），而ECD表達(dá)陽(yáng)性率明顯降低，且伴有轉(zhuǎn)移的膽囊癌ECD表達(dá)更低。膽囊癌的PCNA標(biāo)記指數(shù)顯著高于膽囊炎組和腺瘤組（P＜0.01）。CEA及PCNA過(guò)度表達(dá)者3年生存率顯著降低（P＜0.01），ECD過(guò)度表達(dá)者3年生存率較陰性者明顯增高（P＜0.05）。結(jié)論 CEA、CA50以及PCNA檢測(cè)可能有助于膽囊腺瘤惡變和膽囊癌的早期診斷，且CEA、PCNA和ECD檢測(cè)可作為膽囊癌預(yù)后判斷的參考指標(biāo)。

引用本文： 閻曉初,嚴(yán)粉琴,柳鳳軒,劉麗梅. 4種腫瘤相關(guān)抗原在膽囊癌組織中的表達(dá)及其意義. 中國(guó)普外基礎(chǔ)與臨床雜志, 2002, 9(2): 80-82. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國(guó)普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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  2. 2. Roa I, Araya JC, Villaseca M, et al. Gallbladder cancer in a high risk area: morphological features and spread patterns \[J\]. Hepatogastroenterology, 1999; 46(27)∶1540.
  3. 3. Albores SJ, Henson DE, Sobin LH. The WHO histological classification of tumors of the gallbadder and extrahepatic bile ducts \[J\]. Cancer, 1992; 70(2)∶410.
  4. 4. 惠延平，黃高升，王文亮.ras、cerb B2癌基因蛋白在胃癌及其癌旁組織的表達(dá)及分布特征 \[J\]. 診斷病理學(xué)雜志，2001； 8（3）∶163.
  5. 5. Tanno S, Obara T, Fujii T, et al. Proliferative potential and Kras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union \[J\]. Cancer, 1998; 83(2)∶267.
  6. 6. Stefanovic D, Novakovic R, Perisic SM, et al. The evaluation of tumor markers levels in determination of surgical procedure in patients with gallbladder carcinoma \[J\]. Med Pregl, 1993; 46(Suppl 1)∶58.
  7. 7. Kawa S, Tokoo M, Hasebe O, et al. Comparative study of CA50 and CA242 for the diagnosis of pancreatic cancer \[J\]. Br J Cancer,1994; 70（3）∶481.
  8. 8. Sasatomi E, Tokunaga O, Miyazaki K, et al. Spontaneous apoptosis in gallbladder carcinoma. Relationships with clinicopathologic factors, expression of Ecadherin, bcl2 protooncogene, and p53 on cosuppressor gene \[J\]. Cancer, 1996; 78(10)∶2101.
  9. 9. 許元鴻，郭仁富，郭克建,等. 增殖細(xì)胞核抗原（PCNA）在原發(fā)性膽囊癌中的表達(dá)及其預(yù)后意義 \[J\]. 中華消化雜志，1998; 18（1）∶10.