• 1.首都醫(yī)科大學(xué)附屬北京復(fù)興醫(yī)院外科（北京100038）;;
  • 2.北京大學(xué)人民醫(yī)院外科（北京100044）;

目的探討腫瘤血管生成對(duì)微轉(zhuǎn)移的影響。方法復(fù)習(xí)國內(nèi)、外文獻(xiàn)，并結(jié)合我們自己所作的工作，綜合分析腫瘤血管生成與微轉(zhuǎn)移的關(guān)系。 結(jié)果腫瘤血管生成是微轉(zhuǎn)移腫瘤發(fā)展的基礎(chǔ)。結(jié)論微轉(zhuǎn)移對(duì)血管生成的依賴性，孕育著腫瘤治療上一場(chǎng)新的革命。

引用本文： 駱成玉 綜述,祝學(xué)光審校. 腫瘤血管生成對(duì)微轉(zhuǎn)移影響的研究進(jìn)展. 中國普外基礎(chǔ)與臨床雜志, 2003, 10(5): 516-518. doi: 復(fù)制

1. 駱成玉. 大腸癌患者外周血中癌細(xì)胞檢測(cè)的臨床意義 [J].中華實(shí)驗(yàn)外科雜志， 1999; 16（3）∶199.
2. 駱成玉，趙丹寧，曾勝. 大腸癌淋巴結(jié)微轉(zhuǎn)移的預(yù)后意義 [J].中華普通外科雜志， 2000; 15（3）∶133.
3. 駱成玉. 大腸癌患者門靜脈血癌細(xì)胞的檢測(cè)及臨床意義 [J].中華外科雜志， 1999; 37（4）∶214.
4. 駱成玉，苑樹俊. 手術(shù)前后大腸癌骨髓微轉(zhuǎn)移的研究 [J].中華實(shí)驗(yàn)外科雜志， 2000; 17（3）∶275.
5. 駱成玉，趙丹寧. 大腸癌淋巴結(jié)微轉(zhuǎn)移的研究 [J].中華外科雜志，2000; 38（2）∶142.
6. Faviana P, Boldrini L, Spisni R, et al.Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression [J]. Oncol Rep, 2002; 9(3)∶617.
7. 駱成玉，趙丹寧，李世擁. 大腸癌術(shù)后血路播散的動(dòng)態(tài)追蹤監(jiān)測(cè) [J]. 中華普通外科雜志, 2001; 16（2）∶118.
8. 駱成玉，趙丹寧，劉元林. 內(nèi)皮抑素對(duì)結(jié)腸癌肝轉(zhuǎn)移的干預(yù)作用 [J]. 中華外科雜志, 2001; 39（3）∶198.
9. 駱成玉，趙丹寧. 腺病毒介導(dǎo)的內(nèi)皮抑素基因轉(zhuǎn)移預(yù)防大腸癌術(shù)后肝轉(zhuǎn)移 [J]. 中華外科雜志, 2002; 40（5）∶375.
10. 駱成玉,趙丹寧,曾勝,等. 大腸癌患者腹腔微量游離癌細(xì)胞的研究 [J]. 中華外科雜志, 2001; 39（6）∶433.
11. 駱成玉，趙丹寧. 術(shù)后復(fù)發(fā)轉(zhuǎn)移的大腸癌血路播散分析 [J].中華普通外科雜志， 2001; 16（5）∶291.
12. Folkman J.Tumour angiogenesis and tissue factor [J]. Nat Med,1996; 2(2)∶167.
13. Ingber DE.Extracellular matrix and cell shape:potential control points for inhibition of angiogenesis [J]. J Cell Biochem, 1991； 47(3)∶236.
14. Lawler J. Thrombospondin1 as an endogenous inhibitor of angiogenesis and tumor growth [J]. J Cell Mol Med, 2002； 6(1)∶1.
15. Brivio F, Lissoni P, Rovelli F,et al. Effects of IL2 preoperative immunotherapy on surgeryinduced changes in angiogenic regulation and its prevention of VEGF increase and IL12 decline [J].Hepatogastroenterology, 2002； 49(44)∶385.
16. Svendsen MN, Werther K, Nielsen HJ, et al.EGF and tumour angiogenesis. Impact of surgery, wound healing, inflammation and blood transfusion [J]. Scand J Gastroenterol, 2002; 37(4)∶373.
17. Chiarug V, Ruggiero M, Magnelli L. Angiogenesis and the unique nature of tumor matrix [J]. Mol Biotechnol, 2002; 21(1)∶85.
18. Yokoyama M, Ochi K, Ichimura M, et al. Matrix metalloproteinase2 in pancreatic juice for diagnosis of pancreatic cancer [J]. Pancreas, 2002; 24(4)∶344.
19. McNamara DA, Harmey JH, Walsh TN, et al. Significance of angiogenesis in cancer therapy [J]. Br J Surg, 1998; 85(8)∶1044.
20. 駱成玉，曾勝，趙丹寧，等. 肌肉注射內(nèi)皮抑素基因抑制人大腸癌生長的研究 [J].中華實(shí)驗(yàn)外科雜志， 2001; 18(5)∶443.
21. O’Reilly MS, Boehm T, Shing Y, et al.Endostatin: an endogenous inhibitor of angiogenesis and tumor growth [J]. Cell, 1997; 88(2)∶277.
22. Teicher BA, Emi Y, Kakeji Y, et al.TNP470/Minocycline/cytotoxic therapy: a systems approach to cancer therapy [J]. Eur J Cancer, 1996; 32A(14)∶2461.
23. Kakeji Y, Maehara Y, Sumiyoshi Y, et al. Angiogenesis as a target for gastric cancer [J]. Surgery, 2002; 131(1 Suppl)∶S48.
24. Papetti M, Herman IM. Mechanisms of normal and tumorderived angiogenesis [J]. Am J Physiol Cell Physiol， 2002; 282(5)∶C947.
25. Mohr L, Shankara S, Yoon SK, et al.Gene therapy of hepatocellar carcinoma in vitro and in vovo in nude mice by adenoviral transfer of the Escherichia coli purine nucleoside phosphorylase gene [J]. Hepatology, 2000; 31(3)∶606.
26. Skobe M, Rockwell P, Goldstein N, et al.Halting angiogenesis supresses carcinoma cell invasion [J].Nat Med, 1997; 3(11)∶1222.
  1. 1. 駱成玉. 大腸癌患者外周血中癌細(xì)胞檢測(cè)的臨床意義 [J].中華實(shí)驗(yàn)外科雜志， 1999; 16（3）∶199.
  2. 2. 駱成玉，趙丹寧，曾勝. 大腸癌淋巴結(jié)微轉(zhuǎn)移的預(yù)后意義 [J].中華普通外科雜志， 2000; 15（3）∶133.
  3. 3. 駱成玉. 大腸癌患者門靜脈血癌細(xì)胞的檢測(cè)及臨床意義 [J].中華外科雜志， 1999; 37（4）∶214.
  4. 4. 駱成玉，苑樹俊. 手術(shù)前后大腸癌骨髓微轉(zhuǎn)移的研究 [J].中華實(shí)驗(yàn)外科雜志， 2000; 17（3）∶275.
  5. 5. 駱成玉，趙丹寧. 大腸癌淋巴結(jié)微轉(zhuǎn)移的研究 [J].中華外科雜志，2000; 38（2）∶142.
  6. 6. Faviana P, Boldrini L, Spisni R, et al.Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression [J]. Oncol Rep, 2002; 9(3)∶617.
  7. 7. 駱成玉，趙丹寧，李世擁. 大腸癌術(shù)后血路播散的動(dòng)態(tài)追蹤監(jiān)測(cè) [J]. 中華普通外科雜志, 2001; 16（2）∶118.
  8. 8. 駱成玉，趙丹寧，劉元林. 內(nèi)皮抑素對(duì)結(jié)腸癌肝轉(zhuǎn)移的干預(yù)作用 [J]. 中華外科雜志, 2001; 39（3）∶198.
  9. 9. 駱成玉，趙丹寧. 腺病毒介導(dǎo)的內(nèi)皮抑素基因轉(zhuǎn)移預(yù)防大腸癌術(shù)后肝轉(zhuǎn)移 [J]. 中華外科雜志, 2002; 40（5）∶375.
  10. 10. 駱成玉,趙丹寧,曾勝,等. 大腸癌患者腹腔微量游離癌細(xì)胞的研究 [J]. 中華外科雜志, 2001; 39（6）∶433.
  11. 11. 駱成玉，趙丹寧. 術(shù)后復(fù)發(fā)轉(zhuǎn)移的大腸癌血路播散分析 [J].中華普通外科雜志， 2001; 16（5）∶291.
  12. 12. Folkman J.Tumour angiogenesis and tissue factor [J]. Nat Med,1996; 2(2)∶167.
  13. 13. Ingber DE.Extracellular matrix and cell shape:potential control points for inhibition of angiogenesis [J]. J Cell Biochem, 1991； 47(3)∶236.
  14. 14. Lawler J. Thrombospondin1 as an endogenous inhibitor of angiogenesis and tumor growth [J]. J Cell Mol Med, 2002； 6(1)∶1.
  15. 15. Brivio F, Lissoni P, Rovelli F,et al. Effects of IL2 preoperative immunotherapy on surgeryinduced changes in angiogenic regulation and its prevention of VEGF increase and IL12 decline [J].Hepatogastroenterology, 2002； 49(44)∶385.
  16. 16. Svendsen MN, Werther K, Nielsen HJ, et al.EGF and tumour angiogenesis. Impact of surgery, wound healing, inflammation and blood transfusion [J]. Scand J Gastroenterol, 2002; 37(4)∶373.
  17. 17. Chiarug V, Ruggiero M, Magnelli L. Angiogenesis and the unique nature of tumor matrix [J]. Mol Biotechnol, 2002; 21(1)∶85.
  18. 18. Yokoyama M, Ochi K, Ichimura M, et al. Matrix metalloproteinase2 in pancreatic juice for diagnosis of pancreatic cancer [J]. Pancreas, 2002; 24(4)∶344.
  19. 19. McNamara DA, Harmey JH, Walsh TN, et al. Significance of angiogenesis in cancer therapy [J]. Br J Surg, 1998; 85(8)∶1044.
  20. 20. 駱成玉，曾勝，趙丹寧，等. 肌肉注射內(nèi)皮抑素基因抑制人大腸癌生長的研究 [J].中華實(shí)驗(yàn)外科雜志， 2001; 18(5)∶443.
  21. 21. O’Reilly MS, Boehm T, Shing Y, et al.Endostatin: an endogenous inhibitor of angiogenesis and tumor growth [J]. Cell, 1997; 88(2)∶277.
  22. 22. Teicher BA, Emi Y, Kakeji Y, et al.TNP470/Minocycline/cytotoxic therapy: a systems approach to cancer therapy [J]. Eur J Cancer, 1996; 32A(14)∶2461.
  23. 23. Kakeji Y, Maehara Y, Sumiyoshi Y, et al. Angiogenesis as a target for gastric cancer [J]. Surgery, 2002; 131(1 Suppl)∶S48.
  24. 24. Papetti M, Herman IM. Mechanisms of normal and tumorderived angiogenesis [J]. Am J Physiol Cell Physiol， 2002; 282(5)∶C947.
  25. 25. Mohr L, Shankara S, Yoon SK, et al.Gene therapy of hepatocellar carcinoma in vitro and in vovo in nude mice by adenoviral transfer of the Escherichia coli purine nucleoside phosphorylase gene [J]. Hepatology, 2000; 31(3)∶606.
  26. 26. Skobe M, Rockwell P, Goldstein N, et al.Halting angiogenesis supresses carcinoma cell invasion [J].Nat Med, 1997; 3(11)∶1222.