【摘要】目的 探討CO2氣腹對(duì)肝硬變大鼠腸道黏膜通透性的影響。 方法 建立肝硬變大鼠模型。50只大鼠隨機(jī)分為對(duì)照組(n=5),肝硬變組(n=5)及肝硬變氣腹組(n=40), 肝硬變氣腹組根據(jù)不同氣腹壓又分為8 mm Hg和13 mm Hg 2個(gè)亞組,每組20只。各組大鼠(肝硬變氣腹組分別在氣腹結(jié)束后0.5、2、6及 12 h)取門靜脈血檢測(cè)血清內(nèi)毒素及D乳酸含量。 結(jié)果 肝硬變組血清內(nèi)毒素及D乳酸含量均明顯高于對(duì)照組（P＜0.05）； 而肝硬變氣腹組不同氣腹壓及持續(xù)不同時(shí)間后的血清D乳酸及內(nèi)毒素含量則均明顯高于肝硬變組（P＜0.05），其中血清內(nèi)毒素含量隨氣腹壓增高而增高（13 mm Hg vs 8 mm Hg， F=5.466， P＜0.05），但血清D乳酸含量不同氣腹壓間的差異無(wú)統(tǒng)計(jì)學(xué)意義（F=0.415， P gt;0.05）。 結(jié)論 肝硬變大鼠腸黏膜通透性增加，在此基礎(chǔ)上建立CO2氣腹若增加到一定壓力并持續(xù)一定時(shí)間后，可增加腸黏膜的通透性，且此變化隨氣腹壓力增高而加大，但解除氣腹后可逐漸恢復(fù)。
引用本文： 閆宏憲,羅丁,陳訓(xùn)如,查勇. CO2氣腹對(duì)肝硬變大鼠腸黏膜通透性影響的實(shí)驗(yàn)研究. 中國(guó)普外基礎(chǔ)與臨床雜志, 2005, 12(6): 548-550. doi: 復(fù)制
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