舌下含服尘螨滴剂治疗变应性鼻炎疗效的Meta分析_《中国循证医学杂志》

作者：

崔潇 , 田颖 , 于刚 ,  姜学钧

中国医科大学附属第一医院耳鼻咽喉科（沈阳 110001）;

关键词：

尘螨变应性鼻炎免疫治疗尘螨滴剂系统评价 Meta分析随机对照试验

DOI：

10.7507/1672-2531.20130155

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　系统评价舌下含服尘螨滴剂对变应性鼻炎的疗效。
方法　计算机检索MEDLINE、EMbase、The Cochrane Library（2012年第10期）、CNKI、VIP、WanFang Data和CBM，收集有关舌下含服尘螨滴剂治疗变应性鼻炎的随机对照试验（RCT），检索时限均为从建库至2012年10月。由2名研究者根据纳入和排除标准独立筛选文献、提取资料，并评价纳入研究的方法学质量后，采用 RevMan 5.1 软件进行Meta分析。
结果　纳入8个RCT，共788例患者。Meta分析结果显示：舌下含服尘螨滴剂治疗变应性鼻炎的总有效率与对照组比较无明显差异［RR=1.15，95%CI（0.88，1.50），P=0.29］，但其在降低鼻症状评分［SMD= −1.13，95%CI（−2.07，−0.20），P=0.02 ］和减少药物使用［SMD= −0.60，95%CI（−1.06，−0.15），P=0.009］方面优于对照组。
结论　舌下含服尘螨滴剂可改善变应性鼻炎患者的临床症状，减少抗组胺、β受体阻滞剂及鼻喷激素的使用频率。

引用本文： 崔潇,田颖,于刚,姜学钧. 舌下含服尘螨滴剂治疗变应性鼻炎疗效的Meta分析. 中国循证医学杂志, 2013, 13(7): 885-889. doi: 10.7507/1672-2531.20130155 复制

1.	王成硕, 张罗, 韩德民, 等. 北京地区变应性鼻炎患者吸入变应原谱分析. 临床耳鼻咽喉科杂志, 2006, 20(5): 204-206.
2.	Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.
3.	Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
4.	陈建军, 孔维佳, 项济生, 等. 标准化粉尘螨滴剂治疗变应性鼻炎的半年期疗效济安全性研究. 华中科技大学学报, 2008, 37(6): 823-827.
5.	de Bot CM, Moed H, Berger MY, et al. Sublingual immunotherapy not effective in house dust mite-allergic children in primary care. Pediatric allery and immunology, 2012 23(2): 150-158.
6.	Guez S, Vatrinet C, Fadel R, et al. House-dust-mite sublingual-swallow immunotherapy (SLIT) in perennial rhinitis: a double-blind, placebo-controlled study. Allergy, 2000, 55(4): 369-375.
7.	Passalacqua G, Pasquali M, Ariano R, et al. Randomized double-blind controlled study with sublingual carbamylated allergoid immunotherapy in mild rhinitis due to mites. Allergy, 2006, 61(7): 849-854.
8.	苏芳, 谢景华, 孟庆翔. 粉尘螨疫苗治疗过敏性鼻炎疗效与个体化用药. 河北医学, 2011, 17(6): 772-774.
9.	Tseng SH, Fu LS, Nong BR, et al. Changes in serum specific IgG4 and IgG4/IgE ratio in mite-sensitized Taiwanese children with allergic rhinitis receiving short-term sublingual-swallow immunotherapy: a multicenter, randomized, placebo-controlled trial. Asian Pac J Allergy Immunol, 2008, 26(2-3): 105-112.
10.	谢永汉, 林福荣, 范振兰. 舌下含服粉尘螨滴剂治疗变应性鼻炎100例临床分析. 临床医药实践, 2009, 18(6): 462-464.
11.	Yonekura S, Okamoto Y, Sakurai D, et al. Sublingual immunotherapy with house dust extract for house dust-mite allergic rhinitis in children. Allergol Int, 2010 59(4): 381-388.
12.	NOON L. Prophylactic inoculation against hay fever. Int Arch Allergy Appl Immunol, 1953, 4(4): 285-288.
13.	Compalati E, Passalacqua G, Bonini M, et al. The efficacy of sublingual immunotherapy for house dust mites respiratory allergy: results of a GA2LEN meta-analysis. Allergy, 2009 64(11): 1570-1579.
14.	Ippoliti F, De Sanctis W, Volterrani A, et al. Immunomodulation during sublingual therapy in allergic children. Pediatr Allergy Immunol, 2003, 14(3): 216-221.
15.	Lue KH, Lin YH, Sun HL, et al. Clinical and immunologic effects of sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, randomized placebo-controlled study. Pediatr Allergy Immunol, 2006, 17(6): 408-415.
16.	Moingeon P, Batard T, Fadel R, et al. Immune mechanisms of allergen-specific sublingual immunotherapy. Allergy, 2006, 61(2): 151-165.
17.	Lu FM, Chou CC, Chiang BL, et al. Immunologic changes during immunotherapy in asthmatic children: increased IL-13 and allergen-specific IgG4 antibody levels. Ann Allergy Asthma Immunol, 1998, 80(5): 419-423.
18.	Pajno GB. Sublingual immunotherapy: the optimism and the issues. J Allergy Clin Immunol, 2007, 119(4): 796-801.
19.	Passalacqua G, Durham SR. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol, 2007, 119(4): 881-891.
20.	Pfaar O, Klimek L. Efficacy and safety of specific immunotherapy with a high-dose sublingual grass pollen preparation: a double-blind, placebo-controlled trial. Ann Allergy Asthma Immunol, 2008, 100(3): 256-263.

1. 王成硕, 张罗, 韩德民, 等. 北京地区变应性鼻炎患者吸入变应原谱分析. 临床耳鼻咽喉科杂志, 2006, 20(5): 204-206.
2. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.
3. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med, 2002, 21(11): 1539-1558.
4. 陈建军, 孔维佳, 项济生, 等. 标准化粉尘螨滴剂治疗变应性鼻炎的半年期疗效济安全性研究. 华中科技大学学报, 2008, 37(6): 823-827.
5. de Bot CM, Moed H, Berger MY, et al. Sublingual immunotherapy not effective in house dust mite-allergic children in primary care. Pediatric allery and immunology, 2012 23(2): 150-158.
6. Guez S, Vatrinet C, Fadel R, et al. House-dust-mite sublingual-swallow immunotherapy (SLIT) in perennial rhinitis: a double-blind, placebo-controlled study. Allergy, 2000, 55(4): 369-375.
7. Passalacqua G, Pasquali M, Ariano R, et al. Randomized double-blind controlled study with sublingual carbamylated allergoid immunotherapy in mild rhinitis due to mites. Allergy, 2006, 61(7): 849-854.
8. 苏芳, 谢景华, 孟庆翔. 粉尘螨疫苗治疗过敏性鼻炎疗效与个体化用药. 河北医学, 2011, 17(6): 772-774.
9. Tseng SH, Fu LS, Nong BR, et al. Changes in serum specific IgG4 and IgG4/IgE ratio in mite-sensitized Taiwanese children with allergic rhinitis receiving short-term sublingual-swallow immunotherapy: a multicenter, randomized, placebo-controlled trial. Asian Pac J Allergy Immunol, 2008, 26(2-3): 105-112.
10. 谢永汉, 林福荣, 范振兰. 舌下含服粉尘螨滴剂治疗变应性鼻炎100例临床分析. 临床医药实践, 2009, 18(6): 462-464.
11. Yonekura S, Okamoto Y, Sakurai D, et al. Sublingual immunotherapy with house dust extract for house dust-mite allergic rhinitis in children. Allergol Int, 2010 59(4): 381-388.
12. NOON L. Prophylactic inoculation against hay fever. Int Arch Allergy Appl Immunol, 1953, 4(4): 285-288.
13. Compalati E, Passalacqua G, Bonini M, et al. The efficacy of sublingual immunotherapy for house dust mites respiratory allergy: results of a GA2LEN meta-analysis. Allergy, 2009 64(11): 1570-1579.
14. Ippoliti F, De Sanctis W, Volterrani A, et al. Immunomodulation during sublingual therapy in allergic children. Pediatr Allergy Immunol, 2003, 14(3): 216-221.
15. Lue KH, Lin YH, Sun HL, et al. Clinical and immunologic effects of sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, randomized placebo-controlled study. Pediatr Allergy Immunol, 2006, 17(6): 408-415.
16. Moingeon P, Batard T, Fadel R, et al. Immune mechanisms of allergen-specific sublingual immunotherapy. Allergy, 2006, 61(2): 151-165.
17. Lu FM, Chou CC, Chiang BL, et al. Immunologic changes during immunotherapy in asthmatic children: increased IL-13 and allergen-specific IgG4 antibody levels. Ann Allergy Asthma Immunol, 1998, 80(5): 419-423.
18. Pajno GB. Sublingual immunotherapy: the optimism and the issues. J Allergy Clin Immunol, 2007, 119(4): 796-801.
19. Passalacqua G, Durham SR. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol, 2007, 119(4): 881-891.
20. Pfaar O, Klimek L. Efficacy and safety of specific immunotherapy with a high-dose sublingual grass pollen preparation: a double-blind, placebo-controlled trial. Ann Allergy Asthma Immunol, 2008, 100(3): 256-263.

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舌下含服尘螨滴剂治疗变应性鼻炎疗效的Meta分析

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《中国循证医学杂志》

舌下含服尘螨滴剂治疗变应性鼻炎疗效的Meta分析

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