氟比洛芬酯和利多卡因联用缓解异丙酚注射痛的随机对照研究_《中国循证医学杂志》

作者：

李毅 , 司琪 ,  江晓菁

中国医科大学附属第一临床学院麻醉科（沈阳?110001）;

关键词：

氟比洛芬酯利多卡因异丙酚注射痛随机对照试验

DOI：

10.7507/1672-2531.20110210

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　探讨联合应用氟比洛芬酯和利多卡因做静脉预处理缓解异丙酚注射痛的效果。
方法　将160例拟行择期手术的ASI 1～2级全麻患者随机分为对照组、利多卡因组（Lc组）、氟比洛芬酯组（FA组）和氟比洛芬酯和利多卡因联用组（联用组），每组各40例。所有患者在给药前均先以橡胶止血带阻断其局部静脉回流，随后分别给予对照组0.9% NS 7 mL，FA组氟比洛芬酯注射液5 mL（50 mg）+0.9% NS 2 mL，Lc组2%利多卡因 2 mL（40 mg）+0.9% NS 5 mL，联用组氟比洛芬酯注射液5 mL（50 mg）+2%利多卡因2 mL（40 mg）；2 min后撤止血带，在5 s内给入0.5 mg/kg的异丙酚。给药同时由另一位麻醉师以相同的方式及问题询问患者注射部位情况，采用VRS评分。
结果　4组间一般情况比较无明显差异。Lc组、FA组、联用组的异丙酚注射痛发生率明显低于对照组（P lt;0.05），联用组疼痛发生率低于其余3组。在注射痛强度评分方面，Lc组和联用组的疼痛强度明显低于对照组。术后24 h随访，患者注射部位无红肿、静脉炎或药疹等不良反应情况，亦无预期的胃肠刺激症状。
结论　氟比洛芬酯和利多卡因联用做静脉预处理可有效缓解异丙酚注射痛，且不会增加不良反应。

引用本文： 李毅,司琪,江晓菁. 氟比洛芬酯和利多卡因联用缓解异丙酚注射痛的随机对照研究. 中国循证医学杂志, 2011, 11(11): 1247-1250. doi: 10.7507/1672-2531.20110210 复制

1.	1 Macario A, Weinger M, Truong P, et al . Which clinical anesthesia outcomes are both common and important to avoid? The perspective of a panel of expert anesthesiologists. Anesth Analg , 1999, 88(5): 1085-1091.
2.	2 Hynyen M, Korttila K, Tammisto T. Pain on i.v. injection of propofol (ICI 35 868) in emulsion formulation: Short communication. Acta Anaesthesiologica Scandinavica , 1985, 29(6): 651-652.
3.	3 McCirrick A, Hunter S. Pain on injection of propofol: The effect of injectate temperature. Anaesthesia , 1990, 45(12): 1090-1091.
4.	4 Scott RP, Saunders DA, Norman J. Propofol: Clinical strategies for preventing the pain of injection. Anaesthesia , 1988, 43(6): 492-494.
5.	5 Pascale P, Tramèr MR. Prevention of Pain on Injection with Propofol: A Quantitative Systematic Review. Anesth Analg , 2000, 90(4): 963-969.
6.	6 Fujii Y, Shiga Y. Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective, randomized, double-blind, vehicle-controlled, dose-finding study in Japanese adult surgical patients. Clinical Therapeutics , 2005, 27(5): 588-593.
7.	7 Fujii Y, Itakura M. Pretreatment With Flurbiprofen Axetil, FlurbiprofenAxetil Preceded by Venous Occlusion, and a Mixture of Flurbiprofen Axetil and Propofol in Reducing Pain on Injection of Propofol in Adult Japanese Surgical Patients: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study. Clinical Therapeutics , 2009, 31(4): 721-727.
8.	9 Fujii Y, Nakayama M. Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients. Clinical Therapeutics , 2007, 29(5): 856-861.
9.	10 Kwak HJ, Min SK, Kim JS, et al . Prevention of propofol-induced pain in children: combination of alfentanil and lidocaine vs alfentanil or lidocaine alone. Br J Anaesth , 2009, 103(3): 410-412.
10.	11 Kwak KH, Ha J, Kim Y, et al . Efficacy of combination intravenous lidocaine and dexamethasone on propofol injection pain: a randomized, double-blind, prospective study in adult Korean surgical patients. Clin Ther , 2008, 30(6): 1113-1119.
11.	13 Mangar D, Holak EJ. Tourniquet at 50mm Hg followed by intravenous lidocaine diminishes hand pain associated with propofol injection. Anesth Analg , 1992, 74(2): 250-252.
12.	14 King SY, Davis FM, Wells JE, et al . Lidocaine for the prevention of pain due to injection of propofol. Anesth Analg , 1992, 74(2): 246-249.
13.	15 Smith I, White PF, Nathanson M, et al . Propofol. An update on its clinical use. Anesthesiology , 1994, 81(4): 1005-1043.
14.	16 Ferreira SH. Peripheral analgesia: Mechanism of the analgesic action of aspirin-like drugs and opiate antagonists. Br J Clin Pkarmacol , 1980, 10(Suppl 2): 237S-244S.
15.	17 Auerswald K, Pfeiffer F, Behrends K, et al . Pain on injection with propofol. Anasthesiol Intensivmed Notfallmed Schmerzther , 2005, 40(5): 259-266.
16.	18 Ohmukai O. Lipo-NSAID preparation. Advanced Drug Delivery Reviews , 1996, 20(2-3): 203-207.
17.	20 Ochroch EA, Mardini IA, Gottschalk A. What is the role of NSAIDs in pre-emptive analgesia? Drugs , 2003, 63(24): 2709-2723.
18.	21 Tan CH, Onsiong MK. Pain on injection of propofol. Anaesthesia , 1998, 53(5): 468-476.
19.	马玉姗, 林雪梅, 周俊. 格拉司琼复合利多卡因减轻异丙酚注射痛的随机双盲对照研究. 四川大学学报, 2009, 40(3): 536-538.
20.	Fleisher LA. Preoperative evaluation. In: Barash PG, Cullen BF, Stoelting RK, eds. Clinical Anesthesia. 3rd ed. Philadelphia, Pa: Lippincott-Raven, 1996: 443-459.
21.	Insel PA. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Limbird LE, Molinoff PB, Rudon RW, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill; 1996: 617-657.

1. 1 Macario A, Weinger M, Truong P, et al . Which clinical anesthesia outcomes are both common and important to avoid? The perspective of a panel of expert anesthesiologists. Anesth Analg , 1999, 88(5): 1085-1091.
2. 2 Hynyen M, Korttila K, Tammisto T. Pain on i.v. injection of propofol (ICI 35 868) in emulsion formulation: Short communication. Acta Anaesthesiologica Scandinavica , 1985, 29(6): 651-652.
3. 3 McCirrick A, Hunter S. Pain on injection of propofol: The effect of injectate temperature. Anaesthesia , 1990, 45(12): 1090-1091.
4. 4 Scott RP, Saunders DA, Norman J. Propofol: Clinical strategies for preventing the pain of injection. Anaesthesia , 1988, 43(6): 492-494.
5. 5 Pascale P, Tramèr MR. Prevention of Pain on Injection with Propofol: A Quantitative Systematic Review. Anesth Analg , 2000, 90(4): 963-969.
6. 6 Fujii Y, Shiga Y. Flurbiprofen axetil preceded by venous occlusion in the prevention of pain on propofol injection in the hand: a prospective, randomized, double-blind, vehicle-controlled, dose-finding study in Japanese adult surgical patients. Clinical Therapeutics , 2005, 27(5): 588-593.
7. 7 Fujii Y, Itakura M. Pretreatment With Flurbiprofen Axetil, FlurbiprofenAxetil Preceded by Venous Occlusion, and a Mixture of Flurbiprofen Axetil and Propofol in Reducing Pain on Injection of Propofol in Adult Japanese Surgical Patients: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study. Clinical Therapeutics , 2009, 31(4): 721-727.
8. 9 Fujii Y, Nakayama M. Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients. Clinical Therapeutics , 2007, 29(5): 856-861.
9. 10 Kwak HJ, Min SK, Kim JS, et al . Prevention of propofol-induced pain in children: combination of alfentanil and lidocaine vs alfentanil or lidocaine alone. Br J Anaesth , 2009, 103(3): 410-412.
10. 11 Kwak KH, Ha J, Kim Y, et al . Efficacy of combination intravenous lidocaine and dexamethasone on propofol injection pain: a randomized, double-blind, prospective study in adult Korean surgical patients. Clin Ther , 2008, 30(6): 1113-1119.
11. 13 Mangar D, Holak EJ. Tourniquet at 50mm Hg followed by intravenous lidocaine diminishes hand pain associated with propofol injection. Anesth Analg , 1992, 74(2): 250-252.
12. 14 King SY, Davis FM, Wells JE, et al . Lidocaine for the prevention of pain due to injection of propofol. Anesth Analg , 1992, 74(2): 246-249.
13. 15 Smith I, White PF, Nathanson M, et al . Propofol. An update on its clinical use. Anesthesiology , 1994, 81(4): 1005-1043.
14. 16 Ferreira SH. Peripheral analgesia: Mechanism of the analgesic action of aspirin-like drugs and opiate antagonists. Br J Clin Pkarmacol , 1980, 10(Suppl 2): 237S-244S.
15. 17 Auerswald K, Pfeiffer F, Behrends K, et al . Pain on injection with propofol. Anasthesiol Intensivmed Notfallmed Schmerzther , 2005, 40(5): 259-266.
16. 18 Ohmukai O. Lipo-NSAID preparation. Advanced Drug Delivery Reviews , 1996, 20(2-3): 203-207.
17. 20 Ochroch EA, Mardini IA, Gottschalk A. What is the role of NSAIDs in pre-emptive analgesia? Drugs , 2003, 63(24): 2709-2723.
18. 21 Tan CH, Onsiong MK. Pain on injection of propofol. Anaesthesia , 1998, 53(5): 468-476.
19. 马玉姗, 林雪梅, 周俊. 格拉司琼复合利多卡因减轻异丙酚注射痛的随机双盲对照研究. 四川大学学报, 2009, 40(3): 536-538.
20. Fleisher LA. Preoperative evaluation. In: Barash PG, Cullen BF, Stoelting RK, eds. Clinical Anesthesia. 3rd ed. Philadelphia, Pa: Lippincott-Raven, 1996: 443-459.
21. Insel PA. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Limbird LE, Molinoff PB, Rudon RW, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill; 1996: 617-657.

《中国循证医学杂志》

氟比洛芬酯和利多卡因联用缓解异丙酚注射痛的随机对照研究

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《中国循证医学杂志》

氟比洛芬酯和利多卡因联用缓解异丙酚注射痛的随机对照研究

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