腺苷脱氨酶在结核性浆膜腔积液中诊断价值的循证评价_《中国循证医学杂志》

作者：

李姣 ,  朱渝 , 屈艺 , 母得志

四川大学华西第二医院儿科（成都 610041）;

关键词：

结核性浆膜腔积液腺苷脱氨酶诊断价值系统评价

DOI：

10.7507/1672-2531.20100435

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　探讨腺苷脱氨酶（adenosine deaminase ADA）检测在结核性浆膜腔积液中的诊断价值。
方法　检索PubMed 和CNKI 数据库，查阅关于ADA 在各种结核性浆膜腔积液诊断中应用的相关文献并进行评价。
结果　国内外有多个RCT 和Meta 分析评价了对结核性浆膜腔积液中ADA 活性水平的诊断价值，现有证据表明ADA活性水平测定在各种肺外结核中的诊断敏感性和特异性都很高，各种肺外结核渗出液中ADA 活性水平的最佳阈值为40 IU/L 左右。
结论　检测结核性浆膜腔积液患者渗出液中ADA 活性水平是一个快速、方便、安全有效的结核辅助诊断方法。

引用本文： 李姣,朱渝,屈艺,母得志. 腺苷脱氨酶在结核性浆膜腔积液中诊断价值的循证评价. 中国循证医学杂志, 2010, 10(4): 495-498. doi: 10.7507/1672-2531.20100435 复制

1.	Inadomi JM, Kapur S, Kinkhabwala M, et al. The laparoscopicevaluation of ascites. Gastrointest Endosc Clin N Am, 2001, 11: 79-91.
2.	李钦云, 曹励之. 结核性脑膜炎患儿脑脊液腺苷脱氨酶活力的变化. 北京医学, 2008, 30(3): 432-435.
3.	Giusti G. Adenosine deaminase. In: Bergmeyer H, ed. Methods of Enzymatic Analysis. New York: Academic Press, 1974: 1092-1099.
4.	Slaats EH, Asberg EG, van Keimpema AR, et al. A continuous method for the estimation of adenosine deaminase catalytic concentration in pleural effusions with a Hitachi 705 discrete analyser. J Clin Chem Clin Biochem, 1985, 23: 677-682.
5.	Hillebrand DJ, Runyon BA, Yasmineh WG, et al. Ascitic fluid adenosine deaminase insensitivity in detecting tuberculous peritonitis in the United States. Hepatology, 1996, 24: 1408-1412.
6.	Liang QL, Shi HZ, et al. Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: A meta-analysis. Respiratory Medicine, 2008, 102, 744-754.
7.	Morisson P, Neves DD. Evaluation of adenosine deaminase in the diagnosis of pleural tuberculosis: a Brazilian meta-analysis. J Bras Pneumol, 2008, 34(4): 217-224.
8.	Trautner BW, Darouiche RO. Tuberculous pericarditis:optimal diag nosis and management. Clin Infect Dis, 2001, 33: 954-961.
9.	Cherian G. Diagnosis of tuberculous aetiology in pericardial effusions. Postgrad Med J, 2004, 80: 262-266.
10.	Tuon FF, Litvoc MN. Max Igor Banks Ferreira Lopes Adenosine deaminase and tuberculous pericarditis—A systematic review with meta-analysis. Acta Tropica, 2006, 99: 67-74.
11.	Riquelme A, Calvo M, Salech F, et al. Value of Adenosine Deaminase (ADA) in Ascitic Fluid for the Diagnosis of Tuberculous Peritonitis. J Clin Gastroenterol, 2006, 40: 705-710.
12.	Koh KK, In HH, Lee KH, et al. New scoring system using tumor markers in diagnosing patients with moderate pericardial effusions. Int J Cardiol, 1997, 61: 5-13.
13.	Burgess LJ, Maritz FJ, Le Roux I, et al. Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy. Thorax, 1995, 50: 672-674.

1. Inadomi JM, Kapur S, Kinkhabwala M, et al. The laparoscopicevaluation of ascites. Gastrointest Endosc Clin N Am, 2001, 11: 79-91.
2. 李钦云, 曹励之. 结核性脑膜炎患儿脑脊液腺苷脱氨酶活力的变化. 北京医学, 2008, 30(3): 432-435.
3. Giusti G. Adenosine deaminase. In: Bergmeyer H, ed. Methods of Enzymatic Analysis. New York: Academic Press, 1974: 1092-1099.
4. Slaats EH, Asberg EG, van Keimpema AR, et al. A continuous method for the estimation of adenosine deaminase catalytic concentration in pleural effusions with a Hitachi 705 discrete analyser. J Clin Chem Clin Biochem, 1985, 23: 677-682.
5. Hillebrand DJ, Runyon BA, Yasmineh WG, et al. Ascitic fluid adenosine deaminase insensitivity in detecting tuberculous peritonitis in the United States. Hepatology, 1996, 24: 1408-1412.
6. Liang QL, Shi HZ, et al. Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: A meta-analysis. Respiratory Medicine, 2008, 102, 744-754.
7. Morisson P, Neves DD. Evaluation of adenosine deaminase in the diagnosis of pleural tuberculosis: a Brazilian meta-analysis. J Bras Pneumol, 2008, 34(4): 217-224.
8. Trautner BW, Darouiche RO. Tuberculous pericarditis:optimal diag nosis and management. Clin Infect Dis, 2001, 33: 954-961.
9. Cherian G. Diagnosis of tuberculous aetiology in pericardial effusions. Postgrad Med J, 2004, 80: 262-266.
10. Tuon FF, Litvoc MN. Max Igor Banks Ferreira Lopes Adenosine deaminase and tuberculous pericarditis—A systematic review with meta-analysis. Acta Tropica, 2006, 99: 67-74.
11. Riquelme A, Calvo M, Salech F, et al. Value of Adenosine Deaminase (ADA) in Ascitic Fluid for the Diagnosis of Tuberculous Peritonitis. J Clin Gastroenterol, 2006, 40: 705-710.
12. Koh KK, In HH, Lee KH, et al. New scoring system using tumor markers in diagnosing patients with moderate pericardial effusions. Int J Cardiol, 1997, 61: 5-13.
13. Burgess LJ, Maritz FJ, Le Roux I, et al. Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy. Thorax, 1995, 50: 672-674.

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《中国循证医学杂志》

腺苷脱氨酶在结核性浆膜腔积液中诊断价值的循证评价

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《中国循证医学杂志》

腺苷脱氨酶在结核性浆膜腔积液中诊断价值的循证评价

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