爱普列特对前列腺5α-还原酶活性及雄激素受体水平的影响_《中国循证医学杂志》

作者：

龚志勇 , 崔曙 , 鲜述彦 , 邓显忠 , 王继忠

川北医学院附属医院泌尿外科（四川南充 637000 ）;

关键词：

爱普列特前列腺 5α- 还原酶雄激素受体

DOI：

10.7507/1672-2531.20080232

视频：

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目的　探索爱普列特对前列腺组织5α-还原酶活性及雄激素受体水平的影响。
方法　将40例确诊为良性前列腺增生患者随机分为两组，每组各20例。试验组服用爱普列特以及特拉唑嗪，对照组只服用特拉唑嗪。两周后全部患者行手术取前列腺组织标本，用免疫组化的方法检测40个前列腺标本中5α-还原酶的活性及雄激素受体水平。
结果　试验组前列腺标本中5α-还原酶染色呈弱阳性或阴性，对照组前列腺标本中5α-还原酶染色呈强阳性。40例前列腺标本雄激素受体染色均呈强阳性。
结论　口服爱普列特可明显抑制前列腺内5α-还原酶的活性，但对前列腺内雄激素受体水平无明显影响。

引用本文： 龚志勇,崔曙,鲜述彦,邓显忠,王继忠. 爱普列特对前列腺5α-还原酶活性及雄激素受体水平的影响. 中国循证医学杂志, 2008, 08(12): 1047-1049. doi: 10.7507/1672-2531.20080232 复制

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1. Ranjan M, Diffley P, Stephen G, et al. Comparative study of human steroid 5alpha-reductase isoforms in prostate and female breast skin tissues: sensitivity to inhibition by finasteride and epristeride. Life Sci, 2002, 71(2): 115-126.
2. Johnsonbaugh RE, Cohen BR, McCormack EM, et al. Effect of fourteen days treatment with epristeride, an uncompetitive 5α-reductase inhibitor, on serum and prostatic testosterone and dihydrotestosterone in men with benign prostatic hyperplasia. J Urol, 1993, 149: 423a.
3. Marisa C, Eugene B, Eugenio F, et al. 5α-Reductase inhibitory and antiandrogenic activities of novel steroids in hamster seminal vesicles. Chem Pharm Bull, 2002, 50(11): 1447-1452.
4. Baston E, Salem OI, Hartmann RW, et al. 6-Substituted 3,4-dihydronaphthalene-2-carboxylic acids: synthesis and structure-activity studies in a novel class of human 5-alpha-reductase inhibitors. J Enzyme Inhib Med Chem, 2002, 17(5): 303-320.
5. Qian LH, Wang XL, Tu ZH, et al. Inhibition of regrowth of prostatic glandular cells by epristeride. Acta Pharmacol Sin, 2001, 22(9): 847-850.
6. Bartsch G, Rittmaster RS, Klocker H, et al. Dihydrotestosterone and the concept of 5-alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol, 2002, 19(6): 413-425.
7. Wang LG, Mencher SK, McCarron JP, et al. The biological basis for the use of an anti-androgen and a 5-alpha-reductase inhibitor in the treatment of recurrent prostate cancer: Case report and review. Oncol Rep, 2004, 11(6): 1325-1329.

《中国循证医学杂志》

爱普列特对前列腺5α-还原酶活性及雄激素受体水平的影响

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《中国循证医学杂志》

爱普列特对前列腺5α-还原酶活性及雄激素受体水平的影响

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