脱细胞基质在组织工程气管移植中的研究进展_《中国修复重建外科杂志》

作者：

章方彪 , 张卫东 , 史宏灿

扬州大学临床医学院胸外科（江苏扬州，225001）;

关键词：

气管组织工程脱细胞基质空肠膀胱主动脉

DOI：

10.7507/1002-1892.20130048

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的综述脱细胞基质在组织工程气管中的研究现状、进展及未来前景。方法广泛查阅脱细胞基质在组织工程气管研究中的相关文献，对不同脱细胞基质修复人和动物气管病损的研究现状进行综合分析。结果气管组织工程应用的脱细胞基质包括空肠、膀胱、主动脉和气管。结论脱细胞膀胱基质及空肠基质在修复气管小范围非环形病损中具有较好效果，脱细胞主动脉基质在长段气管病损中的应用还需进一步研究，脱细胞气管基质在长段气管病损中具有良好的应用前景。

引用本文： 章方彪,张卫东,史宏灿. 脱细胞基质在组织工程气管移植中的研究进展. 中国修复重建外科杂志, 2013, 27(2): 223-226. doi: 10.7507/1002-1892.20130048 复制

1.	Whitfield RM, Rinard J, King D. Coverage of megaprosthesis with human acellular dermal matrix after Ewing’s sarcoma resection: a case report. Sarcoma, 2011, 978617.
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4.	Filová E, Straka F, Mirejovský T, et al. Tissue-engineered heart valves. Physiol Res, 2009, 58 suppl 2: S141-158.
5.	Price AP, England KA, Matson AM, et al. Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloaded. Tissue Eng Part A, 2010, 16(8): 2581-2591.
6.	Ozeki M, Narita Y, Kagami H, et al. Evaluation of decellularized esophagus as a scaffold for cultured esophageal epithelial cells. J Biomed Mater Res A, 2006, 79(4): 771-778.
7.	Shupe T, Williams M, Brown A, et al. Method for the decellularization of intact rat liver. Organogenesis, 2010, 6(2): 134-136.
8.	Nakayama KH, Batchelder CA, Lee CI, et al. Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. Tissue Eng Part A, 2010, 16(7): 2207-2216.
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11.	Macchiarini P, Walles T, Biancosino C, et al. First human transplantation of a bioengineered airway tissue. J Thorac Cardiovasc Surg, 2004, 128(4): 638-641.
12.	Voytik-Harbin SL, Brightman AO, Kraine MR, et al. Identification of extractable growth factors from small intestinal submucosa. J Cell Biochem, 1997, 67(4): 478-491.
13.	Park JW, Pavcnik D, Uchida BT, et al. Small intestinal submucosa covered expandable Z stents for treatment of tracheal injury: an experimental pilot study in swine. J Vasc Interv Radiol, 2000, 11(10): 1325-1330.
14.	Gubbels SP, Richardson M, Trune D, et al. Tracheal reconstruction with porcine small intestine submucosa in a rabbit model. Otolaryngol Head Neck Surg, 2006, 134(6): 1028-1035.
15.	Zhang L, Liu Z, Cui P, et al. SIS with tissue-cultured allogenic cartilages patch tracheoplasty in a rabbit model for tracheal defect. Acta Otolaryngol, 2007, 127(6): 631-636.
16.	Du XF, Kwon SK, Song JJ, et al. Tracheal reconstruction by mesenchymal stem cells with small intestine submucosa in rabbits. Int J Pediatr Otorhinolaryngol, 2012, 76(3): 345-351.
17.	Gilbert TW, Gilbert S, Madden M, et al. Morphologic assessment of extracellular matrix scaffolds for patch tracheoplasty in a canine model. Ann Thorac Surg, 2008, 86(3): 967-974.
18.	Makris D, Holder-Espinasse M, Wurtz A, et al. Tracheal replacement with cryopreserved allogenic aorta. Chest, 2010, 137(1): 60-67.
19.	Seguin A, Radu D, Holder-Espinasse M, et al. Tracheal replacement with cryopreserved, decellularized, or glutaraldehyde-treated aortic allografts. Ann Thorac Surg, 2009, 87(3): 861-867.
20.	Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials, 2011, 32(12): 3233-3243.
21.	Haag J, Baiguera S, Jungebluth P, et al. Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue. Biomaterials, 2012, 33(3): 780-789.
22.	Remlinger NT, Czajka CA, Juhas ME, et al. Hydrated xenogeneic decellularized tracheal matrix as a scaffold for tracheal reconstruction. Biomaterials, 2010, 31(13): 3520-3526.
23.	Go T, Jungebluth P, Baiguero S, et al. Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. J Thorac Cardiovasc Surg, 2010, 139(2): 437-443.
24.	Jungebluth P, Go T, Asnaghi A, et al. Structural and morphologic evaluation of a novel detergent-enzymatic tissue-engineered tracheal tubular matrix. J Thorac Cardiovasc Surg, 2009, 138(3): 586-593.
25.	Baiguera S, Birchall MA, Macchiarini P. Tissue-engineered tracheal transplantation. Transplantation, 2010, 89(5): 485-491.
26.	Baiguera S, Del Gaudio C, Jaus MO, et al. Long-term changes to in vitro preserved bioengineered human trachea and their implications for decellularized tissues. Biomaterials, 2012, 33(14): 3662-3672.
27.	Jungebluth P, Moll G, Baiguera S, et al. Tissue-engineered airway: a regenerative solution. Clin Pharmacol Ther, 2012, 91(1): 81-93.
28.	Jungebluth P, Bader A, Baiguera S, et al. The concept of in vivo airway tissue engineering. Biomaterials, 2012, 33(17): 4319-4326.
29.	Kalathur M, Baiguera S, Macchiarini P. Translating tissue-engineered tracheal replacement from bench to bedside. Cell Mol Life Sci, 2010, 67(24): 4185-4196.

1. Whitfield RM, Rinard J, King D. Coverage of megaprosthesis with human acellular dermal matrix after Ewing’s sarcoma resection: a case report. Sarcoma, 2011, 978617.
2. Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissue-engineered airway. Lancet, 2008, 372(9655): 2023-2030.
3. Weymann A, Loganathan S, Takahashi H, et al. Development and evaluation of a perfusion decellularization porcine heart model. Circ J, 2011, 75(4): 852-860.
4. Filová E, Straka F, Mirejovský T, et al. Tissue-engineered heart valves. Physiol Res, 2009, 58 suppl 2: S141-158.
5. Price AP, England KA, Matson AM, et al. Development of a decellularized lung bioreactor system for bioengineering the lung: the matrix reloaded. Tissue Eng Part A, 2010, 16(8): 2581-2591.
6. Ozeki M, Narita Y, Kagami H, et al. Evaluation of decellularized esophagus as a scaffold for cultured esophageal epithelial cells. J Biomed Mater Res A, 2006, 79(4): 771-778.
7. Shupe T, Williams M, Brown A, et al. Method for the decellularization of intact rat liver. Organogenesis, 2010, 6(2): 134-136.
8. Nakayama KH, Batchelder CA, Lee CI, et al. Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. Tissue Eng Part A, 2010, 16(7): 2207-2216.
9. Williams C, Liao J, Joyce EM, et al. Altered structural and mechanical properties in decellularized rabbit carotid arteries. Acta Biomater, 2009, 5(4): 993-1005.
10. Steger V, Hampel M, Trick I, et al. Clinical tracheal replacement: transplantation, bioprostheses and artificial grafts. Expert Rev Med Devices, 2008, 5(5): 605-612.
11. Macchiarini P, Walles T, Biancosino C, et al. First human transplantation of a bioengineered airway tissue. J Thorac Cardiovasc Surg, 2004, 128(4): 638-641.
12. Voytik-Harbin SL, Brightman AO, Kraine MR, et al. Identification of extractable growth factors from small intestinal submucosa. J Cell Biochem, 1997, 67(4): 478-491.
13. Park JW, Pavcnik D, Uchida BT, et al. Small intestinal submucosa covered expandable Z stents for treatment of tracheal injury: an experimental pilot study in swine. J Vasc Interv Radiol, 2000, 11(10): 1325-1330.
14. Gubbels SP, Richardson M, Trune D, et al. Tracheal reconstruction with porcine small intestine submucosa in a rabbit model. Otolaryngol Head Neck Surg, 2006, 134(6): 1028-1035.
15. Zhang L, Liu Z, Cui P, et al. SIS with tissue-cultured allogenic cartilages patch tracheoplasty in a rabbit model for tracheal defect. Acta Otolaryngol, 2007, 127(6): 631-636.
16. Du XF, Kwon SK, Song JJ, et al. Tracheal reconstruction by mesenchymal stem cells with small intestine submucosa in rabbits. Int J Pediatr Otorhinolaryngol, 2012, 76(3): 345-351.
17. Gilbert TW, Gilbert S, Madden M, et al. Morphologic assessment of extracellular matrix scaffolds for patch tracheoplasty in a canine model. Ann Thorac Surg, 2008, 86(3): 967-974.
18. Makris D, Holder-Espinasse M, Wurtz A, et al. Tracheal replacement with cryopreserved allogenic aorta. Chest, 2010, 137(1): 60-67.
19. Seguin A, Radu D, Holder-Espinasse M, et al. Tracheal replacement with cryopreserved, decellularized, or glutaraldehyde-treated aortic allografts. Ann Thorac Surg, 2009, 87(3): 861-867.
20. Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials, 2011, 32(12): 3233-3243.
21. Haag J, Baiguera S, Jungebluth P, et al. Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue. Biomaterials, 2012, 33(3): 780-789.
22. Remlinger NT, Czajka CA, Juhas ME, et al. Hydrated xenogeneic decellularized tracheal matrix as a scaffold for tracheal reconstruction. Biomaterials, 2010, 31(13): 3520-3526.
23. Go T, Jungebluth P, Baiguero S, et al. Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. J Thorac Cardiovasc Surg, 2010, 139(2): 437-443.
24. Jungebluth P, Go T, Asnaghi A, et al. Structural and morphologic evaluation of a novel detergent-enzymatic tissue-engineered tracheal tubular matrix. J Thorac Cardiovasc Surg, 2009, 138(3): 586-593.
25. Baiguera S, Birchall MA, Macchiarini P. Tissue-engineered tracheal transplantation. Transplantation, 2010, 89(5): 485-491.
26. Baiguera S, Del Gaudio C, Jaus MO, et al. Long-term changes to in vitro preserved bioengineered human trachea and their implications for decellularized tissues. Biomaterials, 2012, 33(14): 3662-3672.
27. Jungebluth P, Moll G, Baiguera S, et al. Tissue-engineered airway: a regenerative solution. Clin Pharmacol Ther, 2012, 91(1): 81-93.
28. Jungebluth P, Bader A, Baiguera S, et al. The concept of in vivo airway tissue engineering. Biomaterials, 2012, 33(17): 4319-4326.
29. Kalathur M, Baiguera S, Macchiarini P. Translating tissue-engineered tracheal replacement from bench to bedside. Cell Mol Life Sci, 2010, 67(24): 4185-4196.

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《中国修复重建外科杂志》

脱细胞基质在组织工程气管移植中的研究进展

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《中国修复重建外科杂志》

脱细胞基质在组织工程气管移植中的研究进展

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