血管内皮生长因子、白细胞分化抗原34及CXC趋化因子受体4在转移性鼻咽癌患者鼻咽部肿瘤组织的表达与预后分析_《华西医学》

作者：

罗馨玫 ,  姜愚 , 邹立群 , 冀晓辉 , 邓国华 , 汤捷

四川大学华西医院肿瘤中心/生物治疗国家重点实验室（成都，610041）;

关键词：

转移性鼻咽癌血管内皮生长因子抗原，CD34 受体，CXCR4 预后

DOI：

10.7507/1002-0179.20130442

视频：

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目的　检测血管内皮生长因子（VEGF）、白细胞分化抗原34（CD34）及CXC趋化因子受体4（CXCR4）在转移性鼻咽癌患者鼻咽部肿瘤组织中的表达，探讨它们与鼻咽癌各种临床病理因素的关系以及它们之间的相互联系。方法　采用免疫组织化学链霉素抗生物素蛋白-过氧化物酶连结法检测2003年3月－2009年5月35例转移性鼻咽癌患者VEGF、CD34及CXCR4在鼻咽部肿瘤组织中的表达情况，结合患者临床病理特征进行分析。结果　转移性鼻咽癌患者鼻咽部肿瘤组织中的VEGF及CXCR4阳性表达率分别为62.9%（22∕35）和42.9%（15∕35），CD34计数为11～92，平均43.2 ± 20.5。无肺转移较有肺转移的患者VEGF的阳性表达率高（78.9%、43.8%，P=0.043），多器官转移较单器官转移的患者CXCR4的表达强度高（62.5%、26.3%，P=0.044）。结论　VEGF表达阳性的患者易发生肺转移；CXCR4强表达的患者易发生多器官转移。

引用本文： 罗馨玫,姜愚,邹立群,冀晓辉,邓国华,汤捷. 血管内皮生长因子、白细胞分化抗原34及CXC趋化因子受体4在转移性鼻咽癌患者鼻咽部肿瘤组织的表达与预后分析. 华西医学, 2013, 28(9): 1405-1410. doi: 10.7507/1002-0179.20130442 复制

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2.	Hui EP, Leung SF, Au JS, et al. Lung metastasis alone in nasopharyngeal carcinoma: a relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group[J]. Cancer, 2004, 101(2): 300-306.
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15.	Pan J, Kong L, Lin S, et al. The clinical significance of coexpression of cyclooxygenases-2, vascular endothelial growth factors, and epidermal growth factor receptor in nasopharyngeal carcinoma[J]. Laryngoscope, 2008, 118(11): 1970-1975.
16.	Segawa Y, Oda Y, Yamamoto H, et al. Close correlation between CXCR4 and VEGF expression and their prognostic implications in nasopharyngeal carcinoma[J]. Oncol Rep, 2009, 21(5): 1197-1202.
17.	Chan CM, Ma BB, Hui EP, et al. Cyclooxygenase-2 expression in advanced nasopharyngeal carcinoma--a prognostic evaluation and correlation with hypoxia inducible factor 1alpha and vascular endothelial growth factor[J]. Oral Oncol, 2007, 43(4): 373-378.
18.	Hui EP, Chan AT, Pezzella F, et al. Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydraseⅨ, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival[J]. Clin Cancer Res, 2002, 8(8): 2595-2604.
19.	Kim TJ, Lee YS, Kang JH, et al. Prognostic significance of expression of VEGF and Cox-2 in nasopharyngeal carcinoma and its association with expression of C-erbB2 and EGFR[J]. J Surg Oncol, 2011, 103(1): 46-52.
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22.	Ogawa Y, Chung YS, Nakata B, et al. Microvessel quantitation in invasive breast cancer by staining for factorⅧ-related antigen[J]. Br J Cancer, 1995, 71(6): 1297-1301.
23.	Rubio L, Burgos JS, Morera C, et al. Morphometric study of tumor angiogenesis as a new prognostic factor in nasopharyngeal carcinoma patients[J]. Pathol Oncol Res, 2000, 6(3): 210-216.
24.	Wang N, Wu QL, Fang Y, et al. Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome[J]. J Transl Med, 2005(3): 26.
25.	Murakami T, Maki W, Cardones AR, et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells[J]. Cancer Res, 2002, 62(24): 7328-7334.
26.	Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone[J]. Cancer Cell, 2003, 3(6): 537-549.

1. 　Lo KW, To KF, Huang DP. Focus on nasopharyngeal carcinoma[J]. Cancer Cell, 2004, 5(5): 423-428.
2. 　Hui EP, Leung SF, Au JS, et al. Lung metastasis alone in nasopharyngeal carcinoma: a relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group[J]. Cancer, 2004, 101(2): 300-306.
3. 　Al-Sarraf M, LeBlanc M, Giri PG, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase Ⅲ randomized Intergroup study 0099[J]. J Clin Oncol, 1998, 16(4): 1310-1317.
4. 　Pfrister DG, Aug K, Brizel DM, et al. NCCN clinical practice guidelines in oncology: head and neck cancers[J]. JNCCN, 2011, 11(9): 596-650.
5. 　Wakisaka N, Wen QH, Yoshizaki T, et al. Association of vascular endothelial growth factor expression with angiogenesis and lymph node metastasis in nasopharyngeal carcinoma[J]. Laryngoscope, 1999, 109(5): 810-814.
6. 　Kong HL, Crystal RG. Gene therapy strategies for tumor antiangiogenesis[J]. J Natl Cancer Inst, 1998, 90(4): 273-286.
7. 　Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic Switch during tumorigenesis[J]. Cell, 1996, 86(3): 353-364.
8. 　Ben-Baruch A. Organ selectivity in metastasis: regulation by chemokines and their receptors[J]. Clin Exp Metastasis, 2008, 25(4): 345-356.
9. 　Kato M, Kitayama J, Kazama S, et al. Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma[J]. Breast Cancer Res, 2003, 5(5): R144-R150.
10. 　Liang Z, Yoon Y, Votaw J, et al. Silencing of CXCR4 blocks breast cancer metastasis[J]. Cancer Res, 2005, 65(3): 967-971.
11. 　苏丽萍, 张进平, 陈晋, 等. CXCR4在肺癌组织中的表达及临床意义[J]. 中国癌症杂志, 2005, 15(2): 97-100.
12. 　Brand S, Dambacher J, Beigel F, et al. CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation[J]. Exp Cell Res, 2005, 310(1): 117-130.
13. 　Mattern J, Koomägi R, Volm M. Biological characterization of subgroups of squamous cell lung carcinomas[J]. Clin Cancer Res, 1999, 5(6): 1459-1463.
14. 　Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors[J]. Breast Cancer Res Treat, 1995, 36(2): 169-180.
15. 　Pan J, Kong L, Lin S, et al. The clinical significance of coexpression of cyclooxygenases-2, vascular endothelial growth factors, and epidermal growth factor receptor in nasopharyngeal carcinoma[J]. Laryngoscope, 2008, 118(11): 1970-1975.
16. 　Segawa Y, Oda Y, Yamamoto H, et al. Close correlation between CXCR4 and VEGF expression and their prognostic implications in nasopharyngeal carcinoma[J]. Oncol Rep, 2009, 21(5): 1197-1202.
17. 　Chan CM, Ma BB, Hui EP, et al. Cyclooxygenase-2 expression in advanced nasopharyngeal carcinoma--a prognostic evaluation and correlation with hypoxia inducible factor 1alpha and vascular endothelial growth factor[J]. Oral Oncol, 2007, 43(4): 373-378.
18. 　Hui EP, Chan AT, Pezzella F, et al. Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydraseⅨ, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival[J]. Clin Cancer Res, 2002, 8(8): 2595-2604.
19. 　Kim TJ, Lee YS, Kang JH, et al. Prognostic significance of expression of VEGF and Cox-2 in nasopharyngeal carcinoma and its association with expression of C-erbB2 and EGFR[J]. J Surg Oncol, 2011, 103(1): 46-52.
20. 　Folkman J. What is the evidence that tumors are angiogenesis dependent[J]. J Natl Cancer Inst, 1990, 82(1): 4-6.
21. 　曾俊, 龚玲玲, 陈晓, 等. 微血管密度和血管内皮生长因子、P53表达与鼻咽癌预后的关系[J]. 湖北医科大学学报, 2000, 21(3): 187-189.
22. 　Ogawa Y, Chung YS, Nakata B, et al. Microvessel quantitation in invasive breast cancer by staining for factorⅧ-related antigen[J]. Br J Cancer, 1995, 71(6): 1297-1301.
23. 　Rubio L, Burgos JS, Morera C, et al. Morphometric study of tumor angiogenesis as a new prognostic factor in nasopharyngeal carcinoma patients[J]. Pathol Oncol Res, 2000, 6(3): 210-216.
24. 　Wang N, Wu QL, Fang Y, et al. Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome[J]. J Transl Med, 2005(3): 26.
25. 　Murakami T, Maki W, Cardones AR, et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells[J]. Cancer Res, 2002, 62(24): 7328-7334.
26. 　Kang Y, Siegel PM, Shu W, et al. A multigenic program mediating breast cancer metastasis to bone[J]. Cancer Cell, 2003, 3(6): 537-549.

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血管内皮生长因子、白细胞分化抗原34及CXC趋化因子受体4在转移性鼻咽癌患者鼻咽部肿瘤组织的表达与预后分析

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《华西医学》

血管内皮生长因子、白细胞分化抗原34及CXC趋化因子受体4在转移性鼻咽癌患者鼻咽部肿瘤组织的表达与预后分析

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